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CAS RN: 154229-18-2 | 產品號碼: A2891
Abiraterone Acetate

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產品號碼 | A2891 |
純度/分析方法 | >98.0%(T)(HPLC) |
分子式 / 分子量 | C__2__6H__3__3NO__2 = 391.56 |
外觀與形狀(20°C) | Solid |
儲存條件 | Frozen (<0°C) |
應避免的情況 | Heat Sensitive |
包裝和容器 | 1G-Glass Bottle with Plastic Insert (閲覽圖片), 200MG-Glass Bottle with Plastic Insert (閲覽圖片) |
CAS RN | 154229-18-2 |
Reaxys-RN | 7314563 |
PubChem Substance ID | 253661226 |
MDL編號 | MFCD00934213 |
產品規格
Appearance | White to Light yellow to Light orange powder to crystal |
Purity(HPLC) | min. 98.0 area% |
Purity(Nonaqueous Titration) | min. 98.0 % |
Melting point | 145.0 to 149.0 °C |
Specific rotation [a]20/D | -40.0 to -45.0 deg(C=2,EtOH) |
性質
熔點 | 147 °C |
比旋光 [α]D | -43° (C=2,EtOH) |
GHS
圖形表示 |
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信號詞 | Warning |
危險性說明 | H302 : Harmful if swallowed. H361 : Suspected of damaging fertility or the unborn child. H413 : May cause long lasting harmful effects to aquatic life. |
防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
相關法規
RTECS # | BV7992100 |
運輸資料
HS編碼* | 2937.29-000 |
Application
Abiraterone Acetate: A Prodrug of Abiraterone [A2868]
Abiraterone acetate (CB7630) is a prodrug of abiraterone [A2868] which is a selective inhibitor of the steroidogenic enzyme cytochrome P450 17A1 (CYP17A1) which catalyzes two key serial reactions (17α-hydroxylase hydroxylase and 17,20-lyase) in androgen and estrogen biosynthesis. Abiraterone is more potent than ketoconazole [K0045] as an inhibitor of CYP17. Abiraterone acetate is an agent used in combination with prednisone [P1276] in metastatic castration-resistant prostate cancer (mCRPC). (The product is for research purpose only.)
References
- Pharmacology of novel steroidal inhibitors of cytochrome P45017α (17α-hydroxylase/C17–20 lyase)
- Effects of novel 17α-hydroxylase/C17, 20-lyase (P450 17, CYP 17) inhibitors on androgen biosynthesis in vitro and in vivo
- CYP17 inhibition as a hormonal strategy for prostate cancer
- Abiraterone acetate: in metastatic castration-resistant prostate cancer (a review)
- Abiraterone Acetate: A Review of Its Use in Patients with Metastatic Castration-Resistant Prostate Cancer
考研文獻
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