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CAS RN: 1229-29-4 | 產品號碼: D4626
Doxepin Hydrochloride (mixture of isomers)
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| 產品號碼 | D4626 |
純度/分析方法
|
>98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__1__9H__2__1NO·HCl = 315.84 |
| 外觀與形狀(20°C) | Solid |
儲存條件
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
包裝和容器
|
1G-Glass Bottle with Plastic Insert (閲覽圖片) |
| CAS RN | 1229-29-4 |
相關CAS RN
|
1668-19-5 |
| Reaxys-RN | 5463221 |
| PubChem Substance ID | 253662533 |
| Merck Index(14) | 3435 |
| MDL編號 | MFCD00079135 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 %(total of isomers) |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 186.0 to 190.0 °C |
| NMR | confirm to structure |
性質
| 熔點 | 188 °C |
| Maximum Wavelength | 298 nm |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H301 : Toxic if swallowed. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相關法規
| RTECS # | HQ4375000 |
運輸資料
| UN編號 | UN2811 |
| 類別 | 6.1 |
| 包裝類別 | III |
| HS編碼* | 2932.99-000 |
Application
Doxepin Hydrochloride: A Monoamine Reuptake Inhibitor with a Wide Range of Pharmacological Properties
Doxepin hydrochloride has a wide range of pharmacological properties including an antinoradrenergic property. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H1 and H2 receptors. Doxepin hydrochloride is a family of tricyclic antidepressant agents such as amitriptyline hydrochloride [A0908] and imipramine hydrochloride. (The product is for research purpose only.)
References
- Doxepin up-to-date: a review of its pharmacological properties and therapeutic efficacy with particular reference to depression
- Tricyclic antidepressants as long-acting local anesthetics
- Role of cytochrome P450 2D6 (CYP2D6) in the stereospecific metabolism of E- and Z-doxepin
- Structure of the human histamine H1 receptor complex with doxepin
- Spectrofluorimetric method for the determination of doxepin hydrochloride in commercial dosage forms
PubMed Literature
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