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CAS RN: 1678540-23-2 | 產品號碼: E1267

Ethyl (11bR)-4-Amino-2,6-bis(3,5-di-tert-butylphenyl)-4,5-dihydro-3H-cyclohepta[1,2-a:7,6-a']dinaphthalene-4-carboxylate


纯度/分析方法: >97.0%(HPLC)
別名
  • (11bR)-4-Amino-2,6-bis(3,5-di-tert-butylphenyl)-4,5-dihydro-3H-cyclohepta[1,2-a:7,6-a']dinaphthalene-4-carboxylic Acid Ethyl Ester
文件:
50MG
NT$10,240
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* 以上價格已含運費關稅等但一些需要海運以及乾冰運輸的產品除外,詳情請與 當地經銷商 洽詢。
* TCI會時常優化儲存條件,儲存溫度請以在線目錄為準,敬請留意。


產品號碼 E1267
純度/分析方法 >97.0%(HPLC)
分子式 / 分子量 C__5__4H__6__3NO__2 = 758.10 
外觀與形狀(20°C) Solid
儲存條件 Refrigerated (0-10°C)
應避免的情況 Heat Sensitive
CAS RN 1678540-23-2
PubChem Substance ID 354334205
產品規格
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 97.0 area%
NMR confirm to structure
性質
GHS
圖形表示 Pictogram
信號詞 Warning
危險性說明 H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
防範說明 P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P302 + P352 : IF ON SKIN: Wash with plenty of water.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
相關法規
運輸資料
HS編碼* 2922.49-000
*此H.S.編碼用於日本出口報關, 不適用於您所在國家或地區的進口申報
Application
Decarboxylative Asymmetric Chlorination Using an Asymmetric Catalyst

E1267

Experimental procedure:
To a stirred solution of 1 (10 mol%), N-chlorosuccinimide (1.5 eq.) in toluene is added α-alkyl-β-ketocarboxylic acid (1 eq.) and the reaction mixture is stirred under darkness. After completion, the resulting mixture is subjected directly silica gel column chromatography (hexane:dichloromethane) to give the corresponding α-chloroketone.

References


Application
An Enantioselective Fluorination of α-Branched Aldehydes Using Newly Developed Chiral Amine Catalyst

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E1267, F0335

Typical Procedure (synthesis of 2-fluoro alcohol; Ar=Ph, R1=CH3):
To a solution of the chiral amine catalyst [E1267] (20 mg, 0.026 mmol, 10 mol%) in toluene (0.54 mL) is added 3,5-dinitrobenzoic acid (5.5 mg, 0.026 mmol, 10 mol%), 2-phenylpropionaldehyde (52 mg, 0.39 mmol, 1.5 eq.), and N-fluorobenzenesulfonimide (NFSI) (0.26 mmol, 82 mg, 1 eq.) at 0 °C. The reaction mixture is stirred at 0 °C for 48 h, then poured into CH3OH/CH2Cl2 (1:4, 1.3 mL) at 0 °C. To this solution, NaBH4 (1.6 mmol, 6 eq.) is added, and the mixture is stirred at room temperature for 1 h. The reaction is quenched with saturated aq.NH4Cl, and the mixture is extracted with Et2O. The organic layer is dried over Na2SO4, and concentrated. The residue is purified by silica gel chromatography (eluent: hexane/ethyl acetate = 3/1) to give (S)-2-fluoro-2-phenylpropan-1-ol (34.5 mg, 86% yield based on NFSI, 95% ee) as a white solid.

References


考研文獻


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