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CAS RN: 29110-48-3 | 產品號碼: G0414
Guanfacine Hydrochloride
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| 產品號碼 | G0414 |
純度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__9H__9Cl__2N__3O·HCl = 282.55 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| 包裝和容器
|
100MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 29110-48-3 |
| 相關CAS RN
|
29110-47-2 |
| Reaxys-RN | 6019938 |
| PubChem Substance ID | 253662104 |
| Merck Index(14) | 4561 |
| MDL編號 | MFCD00798230 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 212.0 to 217.0 °C |
性質
| 熔點 | 213 °C |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H301 : Toxic if swallowed. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相關法規
| RTECS # | CY1481000 |
運輸資料
| UN編號 | UN2811 |
| 類別 | 6.1 |
| 包裝類別 | III |
| HS編碼* | 2925.29-000 |
Application
Guanfacine Hydrochloride: A Centrally Acting α2A-Adrenoceptor Agonist
Guanfacine hydrochloride, a phenylacetyl-guanidine derivative, is a centrally acting α2A-adrenoceptor agonist with a mechanism of antihypertensive action similar to that of clonidine [D1353]. It reduces blood pressure in human with essential hypertension (EH) at least as effectively as clonidine or methyldopa [D1817]. Recent research has found that guanfacine can improve prefrontal cortex (PFC) function by strengthening PFC network connections via inhibition of cAMP-potassium channel signaling in postsynaptic spines. Guanfacine is now being used to treat a variety of PFC cognitive disorders, including attention deficit/hyperactivity disorder (ADHD). (The product is for research purpose only.)
References
- Guanfacine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of hypertension
- The alpha-2 adrenergic agonist guanfacine improves memory in aged monkeys without sedative or hypotensive side effects: evidence for alpha-2 receptor subtypes
- The α2-adrenergic agonists clonidine and guanfacine produce tonic and phasic block of conduction in rat sciatic nerve fibers
- The α-2a noradrenergic agonist, guanfacine, improves delayed response performance in young adult rhesus monkeys
- Guanfacine for the treatment of cognitive disorders: a century of discoveries at Yale (a review)
PubMed Literature
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