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CAS RN: 70-00-8 | 產品號碼: T2511
Trifluorothymidine
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補充產品訊息:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| 產品號碼 | T2511 |
純度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__1__0H__1__1F__3N__2O__5 = 296.20 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Hygroscopic |
| 包裝和容器
|
100MG-Glass Bottle with Plastic Insert （閲覽圖片）, 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 70-00-8 |
| Reaxys-RN | 568095 |
| PubChem Substance ID | 87560183 |
| Merck Index(14) | 9687 |
| MDL編號 | MFCD00006534 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Specific rotation [a]20/D | +47.0 to +53.0 deg(C=1, H2O) |
| NMR | confirm to structure |
性質
| 熔點 | 189 °C |
| 比旋光 [α]D | 50° (C=1,H2O) |
| 水溶性 | Soluble |
GHS
相關法規
| RTECS # | XP2087500 |
運輸資料
| HS編碼* | 2940.00-000 |
Application
CRISPR Genome Editing / Research on regenerative medicine
Reference
- Small Molecules Enhance CRISPR Genome Editing in Pluripotent Stem Cells
Application
Trifluridine: A Fluorinated Pyrimidine Nucleoside with Anti-Herpesvirus and Antitumor Activities
Trifluridine (trifluorothymidine, TFT), a fluorinated pyrimidine nucleoside, is an anti-herpesvirus agent and an antitumor antimetabolite agent. Thymidylate kinase (TK) is a key enzyme in the synthesis of thymidine-5'-monophosphate [T0845, di-Na salt], an essential precursor for DNA biosynthesis. Trifluridine is incorporated into (virus or tumor) DNA as its triphosphate via phosphorylation by thymidylate kinase (TK), ultimately suppressing DNA replication and inhibiting cell proliferation.1-4) Trifluridine has activity against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), and vaccinia virus.1-3) Recently, a combined antitumor agent TAS-102 (trifluridine with tipiracil, a thymidine phosphorylase inhibitor) has been used in clinical. Inclusion of tipiracil increases trifluridine exposure by inhibiting its metabolism by thymidine phosphorylase. 4-6) (The product is for research purpose only.)
References
- 1) Fluorinated pyrimidines. XXXVII. Effects of 5-trifluoromethyl-2'-deoxyuridine on the synthesis of deoxyribonucleic acid of mammalian cells in culture
- 2) Trifluorothymidine (a review)
- 3) Trifluridine: a review of its antiviral activity and therapeutic use in the topical treatment of viral eye infections
- 4) Mode of action of trifluorothymidine (TFT) against DNA replication and repair enzymes
- 5) A novel combination antimetabolite, TAS-102, exhibits antitumor activity in FU-resistant human cancer cells through a mechanism involving FTD incorporation in DNA
- 6) TAS-102, a novel antitumor agent: a review of the mechanism of action
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