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CAS RN: 29767-20-2 | 產品號碼: T3109
| 產品號碼 | T3109 |
| 純度/分析方法 | >98.0%(HPLC) |
| 分子式 / 分子量 | C__3__2H__3__2O__1__3S = 656.66 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Frozen (-20°C) |
| 應避免的情況 | Heat Sensitive |
| 包裝和容器 | 100MG-Glass Bottle with Plastic Insert （閲覽圖片）, 20MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 29767-20-2 |
| Reaxys-RN | 7108452 |
| PubChem Substance ID | 253662241 |
| Merck Index(14) | 9145 |
| MDL編號 | MFCD00866516 |
產品規格
| Appearance | White to Almost white powder to crystaline |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation [a]20/D | -107.0 to -115.0 deg(C=1, CHCl3:MeOH=9:1) |
性質
| 熔點 | 247 °C(dec.) |
| 比旋光 [α]D | -111° (C=1,CHCl3:MeOH=9:1) |
| Maximum Wavelength | 283 nm (MeOH) |
| 水溶性 | Insoluble |
| Degree of solubility in water | 5.9 mg/l 25 °C |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H361 : Suspected of damaging fertility or the unborn child. H371 : May cause damage to organs. H372 : Causes damage to organs through prolonged or repeated exposure. H341 : Suspected of causing genetic defects. H350 : May cause cancer. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P405 : Store locked up. |
相關法規
| RTECS # | KC0180000 |
運輸資料
| HS編碼* | 2938.90-000 |
Application
Adeno-associated virus vector transduction enhancer
Teniposide exhibits enhancement of adeno-associated virus transduction.1)
References
- 1) Identification and validation of small molecules that enhance recombinant adeno-associated virus transduction following high-throughput screens
Application
Teniposide: An Inhibitor of Topoisomerase II
Teniposide (VM26) and etoposide (VP16-213) [E0675] are semisynthetic derivatives of podophyllotoxin [P1771], an alkaloid. Teniposide and teniposide are an inhibitor of topoisomerase II such as doxorubicin [D4193], daunorubicin [D4532]. Topoisomerase II is an enzyme essential for DNA replication, chromosome condensation and chromosome segregation. Topoisomerase II inhibitors are potent inducers of double strand breaks in DNA, and can cause arrest in the cell cycle at the G2 stage. Therefore, topoisomerase II inhibitors are the most widely used anti-cancer agents. Teniposide is used for the treatment of acute lymphocytic leukemia (ALL). (The product is for research purpose only.)
References
- The podophyllotoxin derivatives VP16-213 and VM26 (a review)
- The clinical pharmacology of etoposide and teniposide (a review)
- Clinical applications of anticancer drugs targeted to topoisomerase II
- Podophyllotoxin (a review)
- Podophyllotoxin derivatives: current synthetic approaches for new anticancer agents
考研文獻
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