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CAS RN: 220620-09-7 | 產品號碼: T3589
產品號碼 | T3589 |
純度/分析方法 | >98.0%(HPLC) |
分子式 / 分子量 | C__2__9H__3__9N__5O__8 = 585.66 |
外觀與形狀(20°C) | Solid |
儲存條件 | Frozen (<0°C) |
應避免的情況 | Heat Sensitive |
包裝和容器 | 100MG-Glass Bottle with Plastic Insert (閲覽圖片), 500MG-Glass Bottle with Plastic Insert (閲覽圖片) |
CAS RN | 220620-09-7 |
Reaxys-RN | 8379453 |
PubChem Substance ID | 354335260 |
Merck Index(14) | 9432 |
MDL編號 | MFCD00935753 |
產品規格
Appearance | Light yellow to Brown powder to crystal |
Purity(HPLC) | min. 98.0 area% |
Purity(Nonaqueous Titration) | min. 97.0 % |
Specific rotation [a]20/D | -189 to -208 deg(C=0.15, methanol) |
NMR | confirm to structure |
性質
熔點 | 185 °C(dec.) |
比旋光 [α]D | -199° (C=0.15,CH3OH) |
水溶性 | Soluble |
GHS
圖形表示 |
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信號詞 | Danger |
危險性說明 | H318 : Causes serious eye damage. H360 : May damage fertility or the unborn child. H410 : Very toxic to aquatic life with long lasting effects. |
防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P391 : Collect spillage. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. P405 : Store locked up. |
相關法規
RTECS # | QI7619500 |
運輸資料
UN編號 | UN3077 |
類別 | 9 |
包裝類別 | III |
HS編碼* | 2941.30-000 |
Application
Tigecycline: The First Glycylcycline Antimicrobial Agent with Activity against Multidrug-Resistant Strains
Tigecycline (GAR-936) is the first glycylcycline antimicrobial agent with expanded broad-spectrum activity against both Gram-negative (except for Pseudomonas aeruginosa) and Gram-positive aerobes and anaerobes. Furthermore, the spectrum of activity extends to multidrug-resistant strains of Staphylococcus aureus (MRSA), Streptococcus pneumoniae, vancomycin-resistant enterococci (VRE), and Enterobacteriaceae, including extended-spectrum β-lactamase (ESBL) producing strains. In addition, tigecycline is able to overcome the major resistance mechanisms, ribosomal protection and efflux. Tigecycline inhibits protein translation in bacteria by binding to the 30S ribosomal subunit and blocking entry of aminoacyl-tRNA molecules into the A site of the ribosome. Tigecycline binds to bacterial ribosomes in a novel way that allows it to overcome tetracycline resistance due to ribosomal protection. (The product is for research purpose only.)
References
- In vitro and in vivo antibacterial activities of a novel glycylcycline, the 9-t-butylglycylamido derivative of minocycline (GAR-936)
- Functional, biophysical, and structural bases for antibacterial activity of tigecycline
- Tigecycline for the treatment of multidrug-resistant (including carbapenem-resistant) Acinetobacter infections: a review of the scientific evidence (a review)
- Tigecycline: an update (a review)
- Quantitation of tigecycline, a novel glycyclcycline, by liquid chromatography
- Simultaneous analysis of antibiotics in biological samples by ultra high performance liquid chromatography-tandem mass spectrometry
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