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CAS RN: 60-54-8 | 產品號碼: T3971
產品號碼 | T3971 |
純度/分析方法 | >95.0%(T)(HPLC) |
分子式 / 分子量 | C__2__2H__2__4N__2O__8 = 444.44 |
外觀與形狀(20°C) | Solid |
儲存條件 | Refrigerated (0-10°C) |
儲存在惰性氣體下 | Store under inert gas |
應避免的情況 | Light Sensitive,Air Sensitive,Heat Sensitive |
CAS RN | 60-54-8 |
Reaxys-RN | 2230417 |
PubChem Substance ID | 468593045 |
Merck Index(14) | 9196 |
MDL編號 | MFCD00151232 |
產品規格
Appearance | Light yellow to Yellow powder to crystal |
Purity(HPLC) | min. 95.0 area% |
Purity(Volumetric Analysis) | min. 95.0 %(calcd. on anh. substance) |
Water | max. 5.0 % |
NMR | confirm to structure |
性質
熔點 | 164 °C(dec.) |
Maximum Wavelength | 357(H2O) nm |
水溶性 | Insoluble |
Degree of solubility in water | 231 mg/l 25 °C |
溶解性(微溶於) | Alcohol |
溶解性(不溶於) | Chloroform, Ether |
GHS
圖形表示 |
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信號詞 | Warning |
危險性說明 | H302 : Harmful if swallowed. |
防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相關法規
RTECS # | QI8750000 |
運輸資料
HS編碼* | 2941.30-000 |
Application
DNA aptamer research
Reference
- Single-stranded DNA aptamers specific for antibiotics tetracyclines
Application
Tetracycline: a Broad Spectrum Polyketide Antibiotic and a Selective Reagent Genetically Engineered Cells
Tetracycline is a polyketide antibiotic isolated from Streptomyces genus. Tetracycline has broad activity against Gram-negative bacteria and Gram-positive bacteria, with a few exceptions, such as Pseudomonas aeruginosa and Proteus species. Tetracycline inhibits protein synthesis in susceptible organisms by binding to the A-site on the 50S subunit of a bacterial ribosome. However, tetracycline-resistant bacterial strains appeared soon after its introduction. Tetracycline is used in molecular biology as a selective reagent most commonly to isolate bacteria coupled to a gene coding for tetracycline resistance, which is one of the most frequently used selection markers for obtaining transgenic cells. Recently, tetracycline is used for tetracycline-controlled transcriptional activation systems in cells. (The product is for research purpose only.)
References
- Tetracyclines. Antibiotic action, uptake, and resistance mechanisms (a review)
- Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3
- The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit
- Tetracycline resistance determinants: mechanisms of action, regulation of expression, genetic mobility, and distribution (a review)
- Update on acquired tetracycline resistance genes
- In vivo gene regulation using tetracycline-regulatable systems
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