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Base Modified Nucleosides and Nucleotides
It has recently come to light that some bases and riboses in RNA sequences undergo chemical modifications such as methylation after transcription. There are many types of RNA modifications, and more than 150 have been identified in eukaryotes. Most of them are found on tRNAs and are known to affect tRNA stability and translation efficiency.1) In addition, the presence of modified nucleosides have been reported in rRNA, snRNA, and lncRNA. The effects of changes in these modifications on the regulation of gene expression and biological phenomena are drawing attention.2) Since 2012, the research field known as "Epitranscriptomics" has created a major trend in the life sciences as a new regulatory mechanism of gene expression at the post-transcriptional stage.3) Recently, diseases caused by defective RNA modifications and modified RNA expression specific to cancer patients have been reported.4,5)
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