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CAS RN: 280744-09-4 | Product Number: B5716
SB 216763
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Purity: >98.0%(HPLC)
Synonyms:
- 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 10MG |
$162.00
|
1 | 1 | ≥20 |
|
| 50MG |
$483.00
|
Contact Us | Contact Us | ≥20 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | B5716 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__9H__1__2Cl__2N__2O__2 = 371.22 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | <0°C |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 280744-09-4 |
| Reaxys Registry Number | 11333014 |
| PubChem Substance ID | 354335732 |
| MDL Number | MFCD09753369 |
Specifications
| Appearance | Light yellow to Brown powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
Properties (reference)
| Melting Point | 104 °C |
GHS
Related Laws:
Transport Information:
| HS Number | 2933.99.8290 |
Application
SB 216763: An ATP-Competitive Inhibitor of GSK-3α
SB 216763 is reportedly an ATP-competitive inhibitor of glycogen synthase kinase-3α (GSK-3α) in vitro with an IC50 value of 34 nM. GSK-3 is a serine/threonine protein kinase, and inhibition of its activity has been proposed to play a role in the regulation of numerous signalling pathways that elicit cellular responses.
References
- Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription
- Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurons from death
PubMed Literature
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