text.skipToContent text.skipToNavigation

Maximum quantity allowed is 999

Please select the quantity

CAS RN: 1091-85-6 | Product Number: D5406

Dansylglycine [for Albumin binding assay]


Purity: >98.0%(T)
Synonyms:
  • N-[5-(Dimethylamino)naphthalene-1-sulfonyl]glycine
  • Dns-Gly-OH
Documents:
25MG
$18.00
1   1   34  
100MG
$44.00
1   1   25  

* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
* To send your quote request for bulk quantities, please click on the "Request Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.


Product Number D5406
Purity / Analysis Method >98.0%(T)
Molecular Formula / Molecular Weight C__1__4H__1__6N__2O__4S = 308.35 
Physical State (20 deg.C) Solid
Storage Temperature Room Temperature (Recommended in a cool and dark place, <15°C)
Condition to Avoid Light Sensitive
CAS RN 1091-85-6
Reaxys Registry Number 2223701
PubChem Substance ID 354335222
SDBS (AIST Spectral DB) 11221
MDL Number

MFCD00037734

Specifications
Appearance Light yellow to Yellow to Green powder to crystal
Purity(HPLC) min. 97.0 area%
Purity(Neutralization titration) min. 98.0 %
Melting point 156.0 to 161.0 °C
Human serum albmin (HSA) binding activity S/N ratio min. 8
Competitive avtivity in competitive drug Remaining fluorescein inensity max. 30 %
Non-competitive avtivity in non-competitive drug Remaining fluoresein intensity min. 80 %
Properties (reference)
Melting Point 159 °C
GHS
Related Laws:
Transport Information:
HS Number 2935.90.9500
Application
Fluorescent Probes for the Characterization of Two Specific Drug Binding Sites on HSA

Human Serum Albumin (HSA) binds to a wide variety of drugs at two primary binding sites (I: blue and II: yellow), and can have a significant impact on their pharmacokinetics and pharmacological effects. The fluorescent probes, dansylamide (1) and dansylglycine (2) selectively interact with sites I and II, respectively.1,2) BD140 (3) also binds to drug binding site II specifically.3) Changes in probe fluorescence are analyzed by fluorescence titrations as a result of competitive displacement by drugs and pharmaceuticals. The pattern of fluorescent probe displacement by these reagents enabled the identification of two specific drug binding sites, which illustrates their usefulness for the characterization of the binding sites in HSA.

References


PubMed Literature


Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.

The requested SDS is not available.

Please Contact Us for more information.

Specifications
C of A & Other Certificates
Please enter Lot Number Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.

The product with the lot number searched for has been discontinued and no related documentation is available.

Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.

A sample C of A for this product is not available at this time.

Analytical Charts
Please enter Lot Number Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.

The requested analytical chart is not available. Sorry for the inconvenience.

The product with the lot number searched for has been discontinued and no related documentation is available.

Other Documents

Session Status
Your session will timeout in 10 minutes. You will be redirected to the HOME page after session timeout. Please click the button to continue session from the same page. minute. You will be redirected to the HOME page after session timeout. Please click the button to continue session from the same page.

Your session has timed out. You will be redirected to the HOME page.