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CAS RN: 54350-48-0 | Product Number: E1293

Etretinate


Purity: >98.0%(HPLC)
Synonyms:
  • Ethyl all-trans-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoate
  • all-trans-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic Acid Ethyl Ester
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50MG
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Product Number E1293
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__2__3H__3__0O__3 = 354.49  
Physical State (20 deg.C) Solid
CAS RN 54350-48-0
Reaxys Registry Number 2225606
Merck Index (14) 3892
MDL Number

MFCD00866624

Specifications
Appearance White to Yellow to Green powder to crystal
Purity(HPLC) min. 98.0 area%
Melting point 103.0 to 107.0 °C
Properties (reference)
Melting Point 105 °C
Maximum Absorption Wavelength 360(H2O) nm
Solubility in water Insoluble
Solubility (very soluble in) dichloromethane
Solubility (soluble in) Acetone,Ether
Solubility (very slightly) Methanol,Ethanol
GHS
Pictogram Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
H360 : May damage fertility or the unborn child.
H410 : Very toxic to aquatic life with long lasting effects.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P273 : Avoid release to the environment.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P391 : Collect spillage.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P302 + P352 : IF ON SKIN: Wash with plenty of soap and water.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
P362 : Take off contaminated clothing and wash before reuse.
P405 : Store locked up.
Related Laws:
RTECS# RA6620000
Transport Information:
UN Number (DOT-AIR) UN3077
Class (DOT-AIR) 9
Packing Group (TCI-A) III
HS Number 2918.99.4300
Application
Etretinate: A Synthetic Retinoic Acid Derivative that is a Prodrug of Acitretin

Etretinate is a retinoic acid (vitamin A acid) [R0064] derivative that is a prodrug of acitretin [A3097]. Etretinate is used for the treatment of severe psoriasis and other dyskeratoses, but the precise mechanism of action of it is not fully understood. However, the pharmacological profile of etretinate suggests that it acts by normalizing pathological changes in epidermal and dermal skin, particularly inhibiting hyperkeratinization and cell differentiation. In addition, etretinate reportedly has teratogenic potential. (The product is for research purpose only.)

References


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