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CAS RN: 82419-36-1 | Product Number: O0403
Ofloxacin
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 9-Fluoro-3,7-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic Acid
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 5G |
$92.00
|
1 | 1 | ≥40 |
|
| 25G |
$295.00
|
1 | Contact Us | 10 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | O0403 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__8H__2__0FN__3O__4 = 361.37 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| CAS RN | 82419-36-1 |
| Reaxys Registry Number | 3657947 |
| PubChem Substance ID | 172089006 |
| Merck Index (14) | 6771 |
| MDL Number | MFCD00226105 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 263 °C |
| Maximum Absorption Wavelength | 326(H2O) nm |
GHS
Related Laws:
| RTECS# | UU8815500 |
Transport Information:
| HS Number | 2934.99.9001 |
Application
Ofloxacin: A Synthetic Fluoroquinolone Antimicrobial, Ofloxacin
Ofloxacin is a synthetic fluoroquinolone antimicrobial structurally related to nalidixic acid [N0490]. Ofloxacin has broad-spectrum bactericidal activity against most Gram-negative bacteria, many Gram-positive bacteria and some anaerobes. The mechanism of action of ofloxacin (and other fluoroquinolone) involves inhibition of bacterial topoisomerase IV and DNA gyrase (topoisomerases II), enzymes required for DNA replication, transcription, repair and recombination. The active S-(-)-enantiomer of ofloxacin is levofloxacin [L0193]. (The product is for research purpose only.)
References
- Ofloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use
- Quinolones in 2005: an update (a review)
- Moxifloxacin [M2479], ofloxacin, sparfloxacin [S0896], and ciprofloxacin [C2227, C2510] against Mycobacterium tuberculosis: evaluation of in vitro and pharmacodynamic indices that best predict in vivo efficacy
- Synthesis and antibacterial activities of optically active ofloxacin
- Direct determination of four fluoroquinolones, enoxacin [E0762], norfloxacin [N0817], ofloxacin, and ciprofloxacin [C2227, C2510], in pharmaceuticals and blood serum by HPLC
- Determination of ofloxacin, norfloxacin [N0817], and ciprofloxacin [C2227, C2510] in sewage by selective solid-phase extraction, liquid chromatography with fluorescence detection, and liquid chromatography-tandem mass spectrometry
Application
Studies of the Antimicrobial Activity and the Determination of Ofloxacin
References
- Quinolones in 2005: an update
- In vitro and in vivo activity of DL-8280, a new oxazine derivative
- Fourth generation fluoroquinolones: New weapons in the arsenal of ophthalmic antibiotics
- Direct determination of four fluoroquinolones, enoxacin, norfloxacin, ofloxacin, and ciprofloxacin, in pharmaceuticals and blood serum by HPLC
PubMed Literature
Articles/Brochures
TCIMAIL
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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