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CAS RN: 112529-15-4 | Product Number: P1901

Pioglitazone Hydrochloride


Purity: >98.0%(HPLC)(N)
Synonyms:
  • 5-[4-[2-(5-Ethyl-2-pyridyl)ethoxy]benzyl]-2,4-thiazolidinedione Hydrochloride
Documents:
5G
$183.00
17   2   ≥40 
25G
$549.00
2   1   34  

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Product Number P1901
Purity / Analysis Method >98.0%(HPLC)(N)
Molecular Formula / Molecular Weight C__1__9H__2__0N__2O__3S·HCl = 392.90 
Physical State (20 deg.C) Solid
CAS RN 112529-15-4
Related CAS RN 111025-46-8
Reaxys Registry Number 3579575
PubChem Substance ID 125307574
SDBS (AIST Spectral DB) 52915
Merck Index (14) 7452
MDL Number

MFCD04975446

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(with Total Nitrogen) min. 98.0 %
Melting point 190.0 to 197.0 °C
Properties (reference)
Melting Point 191 °C
GHS
Related Laws:
Transport Information:
HS Number 2930.90.2900
Application
Pioglitazone Hydrochloride: An Agonist at the Peroxisome Proliferator-Activated Receptor of the Gamma Subtype (PPARγ)

Pioglitazone hydrochloride, a thiazolidinedione, is an agonist at the peroxisome proliferator-activated receptor of the gamma subtype (PPARγ), a transcription-regulating receptor. PPAR receptors are found in peripheral tissues important for insulin action. Activation of PPARγ nuclear receptors modulates the transcription of a number of insulin responsive genes involved in the control of glucose and lipid metabolism. Therefore, pioglitazone decreases insulin resistance in the periphery tissues and in the liver resulting in increased insulin-dependent glucose disposal and decreased hepatic glucose output. And recently, it has been reported that pioglitazone slows down the progression of Alzheimer's disease. For your reference, [A2567] is a key synthetic intermediate of pioglitazone. (The product is for research purpose only.)

References


PubMed Literature


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