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CAS RN: | Product Number: R0274

Reagents for Condensation Reactions (EDCI·HCl, HOBt·H2O) (HPMC encapsulated)


Purity:
Synonyms:
  • EDCI·HCl ca. 0.25 mmol/capsule, HOBt·H2O ca. 0.04 mmol/capsule (HPMC encapsulated)
Documents:
10EACH
$102.00
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Note:

Contents (per one capsule)

  • EDCI·HCl : ca. 0.25 mmol
  • HOBt Monohydrate : ca. 0.04 mmol

Directions for Use

  • Each capsule contains all reagents for a single use on 0.20 mmol scale condensation reaction (amide coupling reaction) between carboxylic acid and amine. Typical condition: 0.20 mmol of carboxylic acid and 1.0 equiv of amine in water (0.2 M) at 30 °C.

Related Products

  • D1601 EDCI·HCl
  • H0468 HOBt Monohydrate

Product Number R0274
Physical State (20 deg.C) Solid
Storage Temperature Refrigerated (0-10°C)
Store Under Inert Gas Store under inert gas
Condition to Avoid Air Sensitive,Heat Sensitive
Specifications
Appearance White to Almost white capsule
Functionality test (conversion ratio) min. 90.0 %
Properties (reference)
GHS
Pictogram Pictogram Pictogram Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H311 : Toxic in contact with skin.
H302 : Harmful if swallowed.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
H373 : May cause damage to organs through prolonged or repeated exposure.
H317 : May cause an allergic skin reaction.
H410 : Very toxic to aquatic life with long lasting effects.
H228 : Flammable solid.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P273 : Avoid release to the environment.
P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray.
P270 : Do not eat, drink or smoke when using this product.
P240 : Ground/bond container and receiving equipment.
P210 : Keep away from heat/sparks/open flames/hot surfaces. No smoking.
P241 : Use explosion-proof electrical/ ventilating/ lighting/ equipment.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P272 : Contaminated work clothing must not be allowed out of the workplace.
P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish.
P391 : Collect spillage.
P314 : Get medical advice/ attention if you feel unwell.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention.
P362 : Take off contaminated clothing and wash before reuse.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell.
P405 : Store locked up.
Related Laws:
Transport Information:
UN Number (DOT-AIR) UN2926
Class (DOT-AIR) 4.1/6.1
Packing Group (TCI-A) III
HS Number 3822.19.0080
Application
TCI Practical Example: The Condensation Reaction Using a Capsule Reagent

The Condensation Reaction Using a Capsule Reagent

Used Chemicals

Procedure

Reagents for condensation capsule (one capsule) was added to a solution of 4-bromobenzoic acid (40 mg, 0.20 mmol, 1.0 eq.), morpholine (17 μL, 0.20 mmol, 1.0 eq.) in H2O (1 mL) at r.t. and the mixture was stirred at 30 °C for 24 hours. The reaction solution was diluted with sat. Na2SO4 aq. (15 mL) and extracted with ethyl acetate (15 mL x 2), and the organic layer was washed with 2 mol/L HCl aq. (15 mL), sat. NaHCO3 aq. (15 mL) and brine (15 mL). The organic layer was dried over sodium sulfate, concentrated under reduced pressure, and the crude product was purified by silica gel chromatography (ethyl acetate:hexane = 2:1 - 1:1) to afford (4-bromophenyl)(morpholino)methanone (48 mg, 89% yield) as a white solid.

Experimenter’s Comments

The reaction mixture was monitored by UPLC.
The shape of the capsule is like below image and each capsule includes EDCI·HCl (ca. 0.25 mmol) and HOBt·H2O (ca. 0.04 mmol).
The material of the capsule is water-soluble HPMC (hydroxypropyl methylcellulose).

カプセル

Analytical Data

(4-Bromophenyl)(morpholino)methanone

1H NMR (400 MHz, CDCl3); δ 7.57 (d, J = 8.4 Hz, 2H), 7.30 (d, J = 8.4 Hz, 2H), 3.74-3.44 (m, 8H).

Lead Reference

Other Reference


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