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CAS RN: 3945-69-5 | Product Number: R0294

Reagents for Condensation Reactions (DMT-MM) (HPMC encapsulated)


Purity:
Synonyms:
  • DMT-MM ca. 0.30 mmol/capsule (HPMC encapsulated)
Documents:
10EACH
$60.00
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Note:

Contents (per one capsule)

  • DMT-MM : ca. 0.30 mmol

Directions for Use

  • Each capsule contains all reagents for a single use on 0.30 mmol scale condensation reaction (amide coupling reaction) between carboxylic acid and amine.
    Typical condition: 0.30 mmol of carboxylic acid and 1.05 equiv. of amines in methanol (0.20 M) at 30 °C.

Related Products

  • D2919 DMT-MM

Product Number R0294
Molecular Formula / Molecular Weight C__1__0H__1__7ClN__4O__3 = 276.72 
Physical State (20 deg.C) Solid
Storage Temperature Refrigerated (0-10°C)
Condition to Avoid Heat Sensitive
CAS RN 3945-69-5
Specifications
Appearance White to Almost white capsule
Functionality test (conversion ratio) 85.0 %以上
Properties (reference)
GHS
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H302 : Harmful if swallowed.
H314 : Causes severe skin burns and eye damage.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P260 : Do not breathe dust.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower.
P301 + P330 + P331 : IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P363 : Wash contaminated clothing before reuse.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor.
P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor.
P405 : Store locked up.
Related Laws:
Transport Information:
UN Number (DOT-AIR) UN3261
Class (DOT-AIR) 8
Packing Group (TCI-A) II
HS Number 3822.19.0080
Application
TCI Practical Example: Condensation Reaction Using DMT-MM in a Capsule Reagent

TCI Practical Example: Condensation Reaction Using DMT-MM in a Capsule Reagent

Used Chemicals

Procedure

To a solution of 4-bromobenzoic acid (60 mg, 0.30 mmol, 1.0 eq.), morpholine (27.4 μL, 0.315 mmol, 1.05 eq.) in methanol (1.5 mL) was added reagents for condensation capsule (DMT-MM) (one capsule) at r.t. and the mixture was stirred at 30 °C for 24 hours. The reaction solution was diluted with ethyl acetate (20 mL) and filtrated through Celite pad. The filtrate was washed with sat. Na2SO4 aq. (30 mL), 1 mol/L HCl aq. (10 mL), sat. NaHCO3 aq. (15 mL) and brine (15 mL), dried over sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel chromatography (ethyl acetate:hexane = 4:1 - 1:1) to afford (4-bromophenyl)(morpholino)methanone (70 mg, 86% yield) as a white solid.

Experimenter’s Comments

    The reaction mixture was monitored by UPLC.
    The shape of the capsule is like below image and each capsule includes DMT-MM (ca. 0.30 mmol).
    The material of the capsule is water-soluble HPMC (hydroxypropyl methylcellulose).
    Saturated sodium sulfate solution used during partitioning was used to remove HPMC.

    capsule

Analytical Data

(4-Bromophenyl)(morpholino)methanone

1H NMR (400 MHz, DNSO-d6); δ 7.65 (dt, J = 8.9 Hz, 2.1 Hz, 2H), 7.37 (dt, J = 8.5 Hz, 2.1 Hz, 2H), 3.61-3.24 (brm, 8H).

Lead Reference

Other Reference


Documents (Note: Some products will not have analytical charts available.)
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