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CAS RN: 284028-89-3 | Product Number: X0077

XAV 939


Purity: >98.0%(HPLC)
Synonyms:
  • 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one
Documents:
25MG
$274.00
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100MG
$815.00
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Product Number X0077
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__1__4H__1__1F__3N__2OS = 312.31  
Physical State (20 deg.C) Solid
Storage Temperature <0°C
Condition to Avoid Heat Sensitive
CAS RN 284028-89-3
PubChem Substance ID 354333224
MDL Number

MFCD16879017

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Elemental analysis(Nitrogen) 8.00 to 10.00 %
Properties (reference)
GHS
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 : Toxic if swallowed.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P302 + P352 : IF ON SKIN: Wash with plenty of soap and water.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
P362 : Take off contaminated clothing and wash before reuse.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P405 : Store locked up.
Related Laws:
Transport Information:
UN Number (DOT-AIR) UN2811
Class (DOT-AIR) 6.1
Packing Group (TCI-A) III
HS Number 2934.99.4400
Application
Tankyrase Inhibitor

Table. Inhibitoryactivity of XAV 9391)

References

1)Tankyrase inhibition stabilizes axin and antagonizes Wnt signaling

S.-M. A. Huang, Y. M. Mishina, S. Liu, A. Cheung, F. Stegmeier, G. A. Michaud, O. Charlat, E. Wiellette, Y. Zhang, S. Wiessner, M. Hild, X. Shi, C. J. Wilson, C. Mickanin, V. Myer, A. Fazal, R. Tomlinson, F. Serluca, W. Shao, H. Cheng, M. Shultz, C. Rau, M. Schirle, J. Schlegl, S. Ghidelli, S. Fawell, C. Lu, D. Curtis, M. W. Kirschner, C. Lengauer, P. M. Finan, J. A. Tallarico, T. Bouwmeester, J. A. Porter, A. Bauer, F. Cong, Nature 2009, 461, 614.

2)β-Catenin in pluripotency: Adhering to self-renewal or wnting to differentiate?

G. S. Sineva, V. A. Pospelov, Int. Rev. Cell Mol. Biol. 2014, 312, 53.

3)β-catenin signaling promotes differentiation, not self-renewal, of human embryonic stem cells and is repressed by Oct4

K. C. Davidson, A. M. Adams, J. M. Goodson, C. E. McDonald, J. C. Potter, J. D. Berndt, T. L. Biechele, R. J. Taylor, R. T. Moon, Proc. Natl. Acad. Sci. USA 2012, 109, 4485.

4)Successful reprogramming of epiblast stem cells by blocking nuclear localization of β-catenin

H. Murayama, H. Masaki, H. Sato, T. Hayama, T. Yamaguchi, H. Nakauchi, Stem Cell Rep. 2015, 4, 103.

5)Cardiac induction of embryonic stem cells by a small molecule inhibitor of Wnt/β-catenin signaling

H. Wang, J. Hao, C. C. Hong, ACS Chem. Biol. 2011, 6, 192.

6)Small-molecule inhibitors of the Wnt pathway potently promote cardiomyocytes from human embryonic stem cell-derived mesoderm

E. Willems, S. Spiering, H. Davidovics, M. Lanier, Z. Xia, M. Dawson, J. Cashman, M. Mercola, Circ. Res. 2011, 109, 360.


PubMed Literature


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