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Chemical Synthesized Globo-series Oligosaccarides

Globo-series Glycosphingolipids

Glycosphingolipids are expressed tissue-specifically and play important roles in cellular processes such as proliferation, migration, senescence, apoptosis and endocytosis. Globo-series glycolipids also have various biological functions, such as O157 Escherichia coli bacterial toxin receptor [Gb3], breast cancer marker [Globo-H], and early embryo-specific antigen‡ [Gb5 (SSEA-3)/Sialyl Gb5 (SSEA-4)]. In addition, globo-series glycolipids are present in human erythrocytes and are antigens of a very rare blood group called P1PK. TCI has a lineup of a variety of globo-series oligosaccharides prepared by chemical synthesis.

Globo-series Glycosphingolipids

‡Early embryo-specific antigen is also called Stage-Specific Embryonic Antigen (SSEA). Glycan structure changes according to the stage of cell differentiation. Therefore, it is used as a marker for iPS cells and human ES cells.1)

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Relationship between Globo-series Oligosaccarides and Cancer

The globo-series glycosphingolipids include Gb5 (SSEA-3) and Globo H, which play a role in immune suppression and angiogenesis making them targets for potential new therapies.2,3)

Relationship between Globo-series Oligosaccarides and Cancer

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References

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