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Sulfated hyaluronic acid is known to stabilize growth factors, such as FGF1 and FGF2. As a result it is expected to be used as a substitute for sulfated polysaccharides in the context of regenerative medicine as well as in several other fields where sulfated polysaccharides may be needed.
TCI offers sulfated hyaluronic acid with various sulfation degree that can be modified by changing the synthetic reaction.
Maintaining the undifferentiated state of hiPS cell
Sulfated hyaluronic acid maintains the undifferentiated state of hiPS cells underfeeder-free and bFGF-free conditions.
These data were kindly provided by Prof. Shoko Nishihara and Dr. Taichi Miura, Soka University.
Reference
- Highly sulfated hyaluronic acid maintains human induced pluripotent stem cells under feeder-free and bFGF-free conditions
Stabilization of bFGF
Low- and high- sulfated hyaluronic acid were individually added to bFGF and incubated at 37°C for 3 days,
followed by SDS-PAGE and image analysis to calculate the bFGF content.
High-sulfated hyaluronic acid has a greater capacity to preserve bFGF than heparin.
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