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Effective Oxidant for the Alcohol Oxidation and β-Alkyl Enone Synthesis

N-tert-Butylbenzenesulfinimidoyl chloride (1), developed by Matsuo and Mukaiyama et al., is an oxidant and is efficiently used for the oxidation of alcohols at room temperature with ease of handling.1) 1 effectively oxidizes not only typical alcohols but also benzylic and allylic alcohols to aldehydes without complications. Furthermore, 1 is used for the reaction to introduce alkyl groups into the β-position of enones in one pot.2) In this reaction, the 1,4-addition of alkyl copper reagents to enones successfully proceeds to form the enolate 2, and the subsequent reaction with 1 affords the desired β-alkyl enones via the formation of an intermediate 3. In this way, 1 is easy-to-handle and effective in alcohol oxidations and β-alkyl substitutions of enones, so that it is expected to be widely applied for various organic syntheses such as natural products.

B2188

Related Products

B2188
N-tert-Butylbenzenesulfinimidoyl Chloride

References

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