Cobalt Catalyst for the [2+2+2] Cycloaddition Reactions

Cyclopentadienyl(dimethyl fumarate)(triethyl phosphite)cobalt(I) (1) is an air stable and reusable cobalt catalyst. It has been reported that 1 is applicable to [2+2+2] cycloaddition reactions and enables the formation of pyridine rings.¹⁾ For example, [2+2+2] cycloaddition proceeds to form a pyridine ring by heating a diyne and a nitrile by microwave irradiation in the presence of catalytic amount of 1. In addition, 1 is more reactive than CpCo(CO)₂, a general-purpose cobalt catalyst, so that it can be used for the synthesis of benzene rings using triynes as substrates.²⁾

Related Products

C3165

Cyclopentadienyl(dimethyl fumarate)(triethyl phosphite)cobalt(I)

D4940

CpCo(CO)₂

References

• 1) Synthesis of Naphthylpyridines from Unsymmetrical Naphthylheptadiynes and the Configurational Stability of the Biaryl Axis
  • F. Fischer, A. F. Siegle, M. Checinski, C. Fischer, K. Kral, R. Thede, O. Trapp, M. Hapke, J. Org. Chem. 2016, 81, 3087.
• 2) Air-Stable CpCoI–Phosphite–Fumarate Precatalyst in Cyclization Reactions: Comparing Different Methods of Energy Supply
  • F. Fischer, M. Hapke, Eur. J. Org. Chem. 2018, 3193.

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