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DSPE-PEG(2000)-Amine Ammonium Salt for the Preparation of Liposomes and Lipid Nanoparticles
DSPE-PEG(2000)-amine ammonium salt (1) is a synthetic phospholipid formed via modification of the hydrophobic head group of DSPE with an aminated PEG. The PEG moiety of 1 confers improved biocompatibility, while the terminal amine group allows for quick and easy attachment to other molecules containing appropriate functional groups. 1 is primarily used as a major component for the preparation of liposomes and lipid nanoparticles in drug delivery systems (DDS); it has been used to develop targeted therapies against cancer / cancer cell mitochondria,1) Alzheimer's disease,2) as well as photodynamic therapy3) and thermo-chemotherapy.4) Additionally, it has also seen use outside of drug delivery in such fields as molecular targeted imaging.5)
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References
- 1) Liposomes loaded with paclitaxel and modified with novel triphenylphosphonium-PEG-PE conjugate possess low toxicity, target mitochondria and demonstrate enhanced antitumor effects in vitro and in vivo
- 2) Mitochondria-Targeting Ceria Nanoparticles as Antioxidants for Alzheimer's Disease
- 3) Photothermal Conjugated Polymer Nanoparticles for Suppressing Breast Tumor Growth by Regulating TRPA1 Ion Channels
- 4) Targeted temperature sensitive magnetic liposomes for thermo-chemotherapy
- 5) In Vivo Targeted Cancer Imaging, Sentinel Lymph Node Mapping and Multi-Channel Imaging with Biocompatible Silicon Nanocrystals
