DSPE-PEG(2000)-Amine Ammonium Salt for the Preparation of Liposomes and Lipid Nanoparticles

DSPE-PEG(2000)-amine ammonium salt (1) is a synthetic phospholipid formed via modification of the hydrophobic head group of DSPE with an aminated PEG. The PEG moiety of 1 confers improved biocompatibility, while the terminal amine group allows for quick and easy attachment to other molecules containing appropriate functional groups. 1 is primarily used as a major component for the preparation of liposomes and lipid nanoparticles in drug delivery systems (DDS); it has been used to develop targeted therapies against cancer / cancer cell mitochondria,¹⁾ Alzheimer's disease,²⁾ as well as photodynamic therapy³⁾ and thermo-chemotherapy.⁴⁾ Additionally, it has also seen use outside of drug delivery in such fields as molecular targeted imaging.⁵⁾

Related Products

D6011

DSPE-PEG(2000)-Amine Ammonium Salt

D4214

DSPE

Product Category Page

• Phospholipids [Lipids]
• Phospholipids (for DDS)

References

• 1) Liposomes loaded with paclitaxel and modified with novel triphenylphosphonium-PEG-PE conjugate possess low toxicity, target mitochondria and demonstrate enhanced antitumor effects in vitro and in vivo
  • S. Biswas, N. S. Dodwadkar, P. P. Deshpande, V. P. Torchilin, J. Control. Release 2012, 159, 393.
• 2) Mitochondria-Targeting Ceria Nanoparticles as Antioxidants for Alzheimer's Disease
  • H. J. Kwon, M.-Y. Cha, D. Kim, D. K. Kim, M. Soh, K. Shin, T. Hyeon, I. Mook-Jung, ACS Nano 2016, 10, 2860.
• 3) Photothermal Conjugated Polymer Nanoparticles for Suppressing Breast Tumor Growth by Regulating TRPA1 Ion Channels
  • B. Li, S. Ren, D. Gao, N. Li, M. Wu, H. Yuan, M. Zhou, C. Xing, Adv. Healthc. Mater. 2022, 11, 2102506.
• 4) Targeted temperature sensitive magnetic liposomes for thermo-chemotherapy
  • P. Pradhan, J. Giri, F. Rieken, C. Koch, O. Mykhaylyk, M. Döblinger, R. Banerjee, D. Bahadur, C. Plank, J. Control. Release 2010, 142, 108.
• 5) In Vivo Targeted Cancer Imaging, Sentinel Lymph Node Mapping and Multi-Channel Imaging with Biocompatible Silicon Nanocrystals
  • F. Erogbogbo, K.-T. Yong, I. Roy, R. Hu, W.-C. Law, W. Zhao, H. Ding, F. Wu, R. Kumar, M. T. Swihart, P. N. Prasad, ACS Nano 2011, 5, 413.

Page Top