Mediator for Organic Electrochemical Reactions

Recently, organic electrochemical reactions have attracted much attention due to their high functional group tolerance and high energy efficiency, and have been applied to the total synthesis of natural products.^1,2) N-Hydroxytetrachlorophthalimide (TCNHPI) is utilized as a mediator in organic electrochemical reactions. So far, the scalable allylic C-H bond oxidation of terpenes such as valencene and steroids using TCNHPI as a mediator have been reported.³⁾

Related Products

H1765

N-Hydroxytetrachlorophthalimide (= TCNHPI)

B3153

tert-Butyl Hydroperoxide (70% in Water)

L0379

Lithium Perchlorate

References

• 1) Synthetic Organic Electrochemical Methods Since 2000: On the Verge of a Renaissance
  • M. Yan, Y. Kawamata, P. S. Baran, Chem. Rev. 2017, 117, 13230.
• 2) Photons or Electrons? A Critical Comparison of Electrochemistry and Photoredox Catalysis for Organic Synthesis
  • N. E. S. Tay, D. Lehnherr, T. Rovis, Chem. Rev. 2022, 122, 2487.
• 3) Scalable and sustainable electrochemical allylic C–H oxidation
  • E. J. Horn, B. R. Rosen, Y. Chen, J. Tang, K. Chen, M. D. Eastgate, P. S. Baran, Nature 2016, 533, 77.

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