Catechol-containing Methacrylate Monomer for the Development of Biomimetic Materials

3,4-Dihydroxyphenethyl methacrylate (1) is a monomer used for synthesizing biomimetic materials. Mussels adhere to rocks and other surfaces in the sea using a catechol-containing protein called mussel adhesive protein.¹⁾ Numerous adhesives that mimic the function of mussel adhesive protein have been reported, targeting medical and underwater applications.²⁾ N-(3,4-Dihydroxyphenethyl)methacrylamide (2) has been used to introduce the catechol moiety in their synthesis. 1 is an analog of 2 containing a catechol moiety, yet it has been scarcely utilized. The adhesive using 1 exhibit bonding strength comparable to those using 2.³⁾ Furthermore, since 1 possesses ester bonds, improved biodegradability can be expected.

Related Products

D6660

3,4-Dihydroxyphenethyl Methacrylate

D5907

N-(3,4-Dihydroxyphenethyl)methacrylamide

M0591

2-Ethylhexyl Methacrylate

References

• 1) Mussel-inspired biomimetic adhesive coatings for food preservation: a review
  • D. Gupta, D. Bhardwaj, R. Priyadarshi, S. Kumar, G. Agrawal, RSC Appl. Polym. 2025, 3, 1145.
• 2) Mussel-Inspired Molecular Strategies for Fabricating Functional Materials With Underwater Adhesion and Self-Healing Properties
  • P. Huang, H. Zhang, H. Zeng, Adv. Mater. 2025. (early view)
• 3) Hydroxytyrosol: Bioinspired Nature-Based Adhesive Motif with Excellent Chemical Modifiability and Stability
  • T. Fujita, E. Nishi, D. Koma, M. Naito, ACS Appl. Polym. Mater. 2023, 5, 3230.

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