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RNA-dependent RNA polymerase (RdRp) is a key enzyme responsible for RNA virus replication processes and catalyzes the replication of RNA from an RNA template. Because of this, RdRps are often recognized as good targets for antiviral agents.1) The following products, targeting RdRps, have attracted attention for the antiviral activity against RNA viruses, such as SARS-CoV-2, SARS-CoV, MERS-CoV, seasonal and pandemic influenza viruses, and the hepatitis C virus.
- 1) RNA Dependent RNA Polymerases: Insights from Structure, Function and Evolution
- 2) An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice
- 3) T-705 (favipiravir) and related compounds: Novel broad-spectrum inhibitors of RNA viral infections
- 4) The potential chemical structure of anti-SARS-CoV-2 RNA-dependent RNA polymerase
- 5) Ribavirin and lethal mutagenesis of poliovirus: molecular mechanisms, resistance and biological implications
- 6) The Mechanism of Action of β-d-2'-Deoxy-2'-Fluoro-2'-C-Methylcytidine Involves a Second Metabolic Pathway Leading to β-d-2'-Deoxy-2'-Fluoro-2'-C-Methyluridine 5'-Triphosphate, a Potent Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase