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CAS RN: 25561-30-2 | Product Number: B0830
N,O-Bis(trimethylsilyl)trifluoroacetamide
Purity: >95.0%(GC)
Synonyms:
- BSTFA
Product Documents:
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| Product Number | B0830 |
Purity / Analysis Method
|
>95.0%(GC) |
| Molecular Formula / Molecular Weight | C__8H__1__8F__3NOSi__2 = 257.40 |
| Physical State (20 deg.C) | Liquid |
Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Moisture Sensitive,Heat Sensitive |
Packaging and Container
|
100ML-DualSeal Bottle (View image), 25ML-DualSeal Bottle (View image), 5ML-Vial (View image) |
| CAS RN | 25561-30-2 |
| Reaxys Registry Number | 3607620 |
| PubChem Substance ID | 87563814 |
| SDBS (AIST Spectral DB) | 6259 |
| MDL Number | MFCD00008269 |
Specifications
| Appearance | Colorless to Light yellow to Light orange clear liquid |
| Purity(GC) | min. 95.0 % |
Properties (reference)
| Boiling Point | 142 °C |
| Flash point | 24 °C |
| Specific Gravity (20/20) | 0.97 |
| Refractive Index | 1.38 |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H314 : Causes severe skin burns and eye damage. H226 : Flammable liquid and vapor. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P240 : Ground/bond container and receiving equipment. P210 : Keep away from heat/sparks/open flames/hot surfaces. No smoking. P233 : Keep container tightly closed. P243 : Take precautionary measures against static discharge. P241 : Use explosion-proof electrical/ ventilating/ lighting/ equipment. P242 : Use only non-sparking tools. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish. P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. P301 + P330 + P331 : IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P363 : Wash contaminated clothing before reuse. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. P403 + P235 : Store in a well-ventilated place. Keep cool. P405 : Store locked up. |
Related Laws:
Transport Information:
| UN Number | UN2924 |
| Class | 3 / 8 |
| Packing Group | III |
| H.S.code* | 2931.90-000 |
Application
Trimethylsilylating Reagent for GC Derivatization

Experimental procedure:
A dry sample (1 mg) is placed into a vial, (0.24 mL) and BSTFA (0.24 mL) is added. After sealing the vial, it is shaken to become a homogenized solution, and then heated with an oil bath (150 °C) for 15 min. After cooling, it can be used as a GC sample.
A dry sample (1 mg) is placed into a vial, (0.24 mL) and BSTFA (0.24 mL) is added. After sealing the vial, it is shaken to become a homogenized solution, and then heated with an oil bath (150 °C) for 15 min. After cooling, it can be used as a GC sample.
References
- Trimethylsilylation of amino acids derivatization and chromatography
Application
Trimethylsilylation of Alcohols using TMS Reagents

References
- Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols
- P. G. M. Wuts, in Greene’s Protective Groups in Organic Synthesis, 5th ed., ed. by P. G. M. Wuts, John Wiley & Sons, Inc., Hoboken, New Jersey, 2014, Chap. 2, 17.
Application
TMS Protection of Alcohols using BSTFA

References
- Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols
- P. G. M. Wuts, in Greene’s Protective Groups in Organic Synthesis, 5th ed., ed. by P. G. M. Wuts, John Wiley & Sons, Inc., Hoboken, New Jersey, 2014, Chap. 2, 17.
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