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CAS RN: 120410-24-4 | Product Number: B5522
Biapenem
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Purity: >98.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
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|
|---|---|---|---|---|---|
| 25MG |
$104.00
|
0 | 6 | It can be shipped in about 2 weeks after ordering | |
| 100MG |
$316.00
|
13 | 21 | It can be shipped in about 2 weeks after ordering |
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| Product Number | B5522 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__5H__1__8N__4O__4S = 350.39 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 120410-24-4 |
| Reaxys Registry Number | 7394875 |
| Merck Index (14) | 1197 |
| MDL Number | MFCD00864863 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 15.20 to 16.70 % |
| Specific rotation [a]20/D | -30.0 to 335.0 deg(C=0.5, H2O) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 226 °C(dec.) |
| Specific Rotation | -33° (C=0.5,H2O) |
| Solubility in water | Slightly soluble |
| Solubility (insoluble in) | Methanol, Ethanol, Ether |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2941.90-000 |
Application
Biapenem: A Carbapenem Antibacterial Agent against Pseudomonas aeruginosa
Biapenem (LJC 10627) is a carbapenem antibacterial agent that has antibacterial and fungicidal activity against a wide range of Gram-positive and -negative bacteria, including species producing β-lactamases. Biapenem also has activity against Pseudomonas aeruginosa which isolates with broad-spectrum insusceptibility to penicillins and cephalosporins. Biapenem inhibits murein biosynthesis which is needed by bacteria to make their cell walls. In addition, biapenem is more stable than meropenem [M2279] to metabolic hydrolysis by human renal dihydropeptidase-I (DHP-I). (The product is for research purpose only.)
References
- In vitro activity of LJC10,627, a new carbapenem antibiotic with high stability to dehydropeptidase I
- Renal dehydropeptidase-I stability of LJC 10,627, a new carbapenem antibiotic
- In-vitro activity of biapenem, compared with imipenem and meropenem, against Pseudomonas aeruginosa strains and mutants with known resistance mechanisms
- Biochemical comparison of imipenem, meropenem and biapenem: permeability, binding to penicillin-binding proteins, and stability to hydrolysis by β-lactamases
- Biapenem (a review)
- The stability of biapenem and structural identification of impurities in aqueous solution
- A simple and rapid determination of biapenem in plasma by high-performance liquid chromatography
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