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CAS RN: 6001-74-7 | Product Number: C3020
Chlormethiazole Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 5-(2-Chloroethyl)-4-methylthiazole Hydrochloride
- Clomethiazole Hydrochloride
- Somnevrin Hydrochloride
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 200MG |
$101.00
|
12 | 0 | Contact Us | |
| 1G |
$350.00
|
1 | 4 | Contact Us |
* Please contact our distributors or
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to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.
| Product Number | C3020 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__6H__8ClNS·HCl = 198.11 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image), 200MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 6001-74-7 |
| Related CAS RN
|
533-45-9 |
| Reaxys Registry Number | 3697289 |
| PubChem Substance ID | 253662385 |
| Merck Index (14) | 2384 |
| MDL Number | MFCD00673948 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 134.0 to 138.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 136 °C |
| Solubility in water | Soluble |
| Solubility (soluble in) | Alcohol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| H.S.code* | 2934.10-000 |
Application
Chlormethiazole Hydrochloride: A Neuroprotective and a CYP2E1 Inhibitory Agent
Chlormethiazole hydrochloride is a thiazole derivative with sedative and anticonvulsive properties. The mechanism of action is considered to involve the potentiation of GABA [A0282] activity, the major intrinsic inhibitory neurotransmitter. Chlormethiazole is also reported to inhibit cytochrome P 450 2E (CYP2E1) which is suggested to alcoholic liver disease. (The product is for research purpose only.)
References
- Neuroprotective activity of chlormethiazole following transient forebrain ischemia in the gerbil
- The pharmacology of chlormethiazole: a potential neuroprotective agent? (A review)
- Chlormethiazole as an efficient inhibitor of cytochrome P450 2E1 expression in rat liver
- nhibition of ethanol-induced liver disease in the intragastric feeding rat model by chlormethiazole
PubMed Literature
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