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CAS RN: 188817-13-2 | Product Number: C3572
SC-560
×
Purity: >98.0%(HPLC)
Synonyms:
- 5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 25MG |
$103.00
|
0 | 15 | Contact Us | |
| 100MG |
$340.00
|
0 | 4 | Contact Us |
* Please contact our distributors or
TCI
to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.
| Product Number | C3572 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__1__2ClF__3N__2O = 352.74 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
100MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 188817-13-2 |
| Reaxys Registry Number | 7719788 |
| PubChem Substance ID | 468591169 |
| MDL Number | MFCD02179214 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 7.50 to 8.50 % |
| Melting point | 61.0 to 65.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 63 °C |
GHS
Related Laws:
| RTECS# | UQ6457100 |
Transport Information:
| H.S.code* | 2933.19-000 |
Application
SC-560: A Selective Cyclooxygenase-1 (COX-1) Inhibitor
SC-560 is a strucutral analog of celecoxib [C2816] and a member of cyclooxygenase (COX) inhibitors which includes selective COX-2 inhibitors such as celecoxib and rofecoxib [R0206]. However, unlike these selective COX-2 inhibitors, SC-560 is a selective COX-1 inhibitor. Reportedly, SC-560 causes intestinal hypermotility, bacterial invasion, inhibition of prostaglandin E2 synthesis, etc. In addition, SC-560 suppresses cell proliferation and induces apoptosis in cancer cells in the blood. (The product is for research purpose only.)
References
- Pharmacological analysis of cyclooxygenase-1 in inflammation
- NSAID-induced gastric damage in rats: requirement for inhibition of both cyclooxygenase 1 and 2
- Inhibition of prostaglandin E2 synthesis by SC-560 is independent of cyclooxygenase 1 inhibition
- Selective COX-1 inhibition: a therapeutic target to be reconsidered (a review)
- The selective cyclooxygenase-1 inhibitor SC-560 suppresses cell proliferation and induces apoptosis in human hepatocellular carcinoma cells
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