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CAS RN: 54952-43-1 | Product Number: H1780
(±)-Shikonin
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Purity: >98.0%(HPLC)
Synonyms:
- (±)-Alkannin
- (±)-Shikalkin
- (±)-5,8-Dihydroxy-2-(1-hydroxy-4-methylpent-3-en-1-yl)naphthalene-1,4-dione
- (±)-5,8-Dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-1,4-naphthoquinone
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 10MG |
$85.00
|
2 | 0 | It can be shipped in about 2 weeks after ordering | |
| 50MG |
$282.00
|
4 | 0 | It can be shipped in about 2 weeks after ordering |
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* The storage conditions are subject to change without notice.
| Product Number | H1780 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__1__6O__5 = 288.30 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 54952-43-1 |
| PubChem Substance ID | 468592048 |
| MDL Number | MFCD00016668 |
Specifications
| Appearance | Orange to Brown powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 147.0 to 151.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 149 °C |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2914.69-000 |
Application
A Crude Medicine Ingredients with Strong Anticancer Effects
Zicao, a traditional Chinese herbal medicine made from the dried root of Lithospermum erythrorhizon, has been used for the topical treatment of wounds in the form of oil-based ointment for several hundred years.1) The naphthoquinone (±)-shikonin is the main active substance of Zicao, and has been shown to possess many diverse properties including antioxidant, anti-inflammatory, antithrombotic, antimicrobial, and wound healing effects. In particular, many studies have demonstrated that shikonin exerts strong anticancer effects on various types of cancer by anti-angiogenesis, inhibiting cell proliferation and migration, inducing apoptosis, autophagy, and necroptosis.1-4) Shikonin also triggers Reactive Oxygen Species (ROS) generation, suppressing exosome release, and activate anti-tumor immunity in multiple molecular mechanisms.4) (The product is for research purpose only.)
References
- 1) Shikonin, an ingredient of Lithospermum erythrorhizon, inhibits angiogenesis in vivo and in vitro
- 2) Cellular pharmacology studies of shikonin derivatives (a review)
- 3) Pharmacological properties of shikonin - a review of literature since 2002 (a review)
- 4) Pharmacological properties and derivatives of shikonin-A review in recent years (a review)
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