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CAS RN: 147591-46-6 | Product Number: I1108
ID 8
 
									 
							Purity: >98.0%(GC)
Synonyms:
						
						- 1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol
Product Documents:
                    
				
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| Product Number | I1108 | 
| Purity / Analysis Method   | >98.0%(GC) | 
| Molecular Formula / Molecular Weight | C__1__6H__1__4N__2O__4 = 298.30 | 
| Physical State (20 deg.C) | Solid | 
| Storage Temperature   | Frozen (-20°C) | 
| Condition to Avoid | Light Sensitive,Heat Sensitive | 
| Packaging and Container   | 10MG-Glass Bottle with Plastic Insert (View image), 50MG-Glass Bottle with Plastic Insert (View image) | 
| CAS RN | 147591-46-6 | 
| Reaxys Registry Number | 5825601 | 
| PubChem Substance ID | 468592099 | 
| MDL Number | MFCD00593367 | 
Specifications
		  | Appearance | Light yellow to Amber to Dark green powder to crystal | 
| Purity(GC) | min. 98.0 % | 
| NMR | confirm to structure | 
		Properties (reference)
	| Melting Point | 266 °C(dec.) | 
 
						 GHS
						  
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						Transport Information:
							| H.S.code* | 2933.99-000 | 
			Application
		
			Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase (DYRK) Inhibitor
		
		ID 8 (1) was reported as an indole derivative that can sustain embryonic stem cell self-renewal in long-term culture.1)1 inhibits dual-specificity tyrosine phosphorylation-regulated kinase (DYRK).2) 1 supports Wnt-induced human embryonic stem cell proliferation and survival without fibroblast growth factor (FGF) and tumor growth factor-β (TGF-β) supplementation.2)
References
- 1) Indole derivatives sustain embryonic stem cell self-renewal in long-term culture
- 2) Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion
Documents
Product Articles
  		        [TCIMAIL No.188] Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase (DYRK) InhibitorProduct Documents (Note: Some products will not have analytical charts available.)
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Specifications
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