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CAS RN: 256373-96-3 | Product Number: M3396
MCC950 Sodium Salt
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Purity: >95.0%(HPLC)(qNMR)
Synonyms:
- CRID3 Sodium Salt
- CP-456773 Sodium Salt
- Sodium [(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl][[4-(2-hydroxypropan-2-yl)furan-2-yl]sulfonyl]amide
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 10MG |
$186.00
|
2 | 10 | Contact Us |
* Please contact our distributors or
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to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.
| Product Number | M3396 |
Purity / Analysis Method 
|
>95.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__2__0H__2__3N__2NaO__5S = 426.46 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Hygroscopic,Heat Sensitive |
| CAS RN | 256373-96-3 |
| Reaxys Registry Number | 9463223 |
| PubChem Substance ID | 468592442 |
| MDL Number | MFCD30478884 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(qNMR) | min. 95.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 239 °C |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2935.90-000 |
Application
MCC 950 Sodium Salt: A Potent and Selective Small-Molecule Inhibitor of the NLRP3 Inflammasome
It has recently been reported that NLR family pyrin domain-containing protein 3 (NLRP3), a pattern recognition receptor, forms a complex called NLRP3 inflammasome in response to irritating metabolites and pathogens, and induces the production of pro-inflammatory cytokines, Interleukin (IL)-1β and IL-18. MCC950 sodium has attracted attention as a potent and selective NLRP3 inflammasome inhibitor which shows anti-inflammatory activity. (The product is for research purpose only.)
References
- A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
- The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction
- MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition
- Target of MCC950 in Inhibition of NLRP3 Inflammasome Activation: a Literature Review
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