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CAS RN: 28721-07-5 | Product Number: O0363
Oxcarbazepine
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Purity: >98.0%(HPLC)(N)
Synonyms:
- 10,11-Dihydro-10-oxo-5H-dibenzo[b,f]azepine-5-carboxamide
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 5G |
$96.00
|
26 | 0 | Contact Us | |
| 25G |
$276.00
|
22 | 0 | Contact Us |
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| Product Number | O0363 |
Purity / Analysis Method 
|
>98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__1__5H__1__2N__2O__2 = 252.27 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 28721-07-5 |
| Reaxys Registry Number | 1474055 |
| PubChem Substance ID | 87561105 |
| Merck Index (14) | 6929 |
| MDL Number | MFCD00865307 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
Properties (reference)
| Melting Point | 216 °C(dec.) |
| Solubility (soluble in) | Dimethylformamide |
GHS
Related Laws:
| RTECS# | HN8445000 |
Transport Information:
| H.S.code* | 2933.99-000 |
Application
電位依存性ナトリウムチャネル (VGSC) 阻害剤，オクスカルバゼピン
Oxcarbazepine is an antiepileptic agent with a chemical structure similar to carbamazepine [CAS: 298-46-4], adding an extra oxygen atom to the benzylcarboxamide group. Oxcarbazepine was developed to improve the side effect profile of carbamazepine. Oxcarbazepine is rapidly metabolized to 10,11-dihydro-10-hydroxycarbazepine (monohydroxy derivative, MHD) which also has the pharmacological activity. The precise mechanism of action is unknown, but in vitro studies indicate that oxcarbazepine and MHD produce blockade of voltage-sensitive sodium channels (VGSC), resulting in stabilization of hyperexcited neural membranes. (The product is for research purpose only.)
References
- Oxcarbazepine: an update of its efficacy in the management of epilepsy (a review)
- Mechanisms of action of carbamazepine and its derivatives, oxcarbazepine, BIA 2-093 (eslicarbazepine acetate [E1046]), and BIA 2-024 (a review)
- Clinical pharmacokinetics of oxcarbazepine (a review)
- Enantioselective pharmacokinetics of 10-hydroxycarbazepine after oral administration of oxcarbazepine to healthy Chinese subjects
- The use of separation techniques in the analysis of some antiepileptic drugs: A critical review
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