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CAS RN: 763113-22-0 | Product Number: O0689
Olaparib
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Purity: >95.0%(HPLC)
Synonyms:
- AZD-2281
- 4-[3-[4-(Cyclopropanecarbonyl)piperazine-1-carbonyl]-4-fluorobenzyl]phthalazin-1(2H)-one
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
$72.00
|
12 | 0 | Contact Us |
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| Product Number | O0689 |
Purity / Analysis Method 
|
>95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__4H__2__3FN__4O__3 = 434.47 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 763113-22-0 |
| Reaxys Registry Number | 12051534 |
| MDL Number | MFCD13185161 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Melting point | 209.0 to 213.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 211 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H360 : May damage fertility or the unborn child. H372 : Causes damage to organs through prolonged or repeated exposure. H336 : May cause drowsiness or dizziness. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up. |
Related Laws:
| RTECS# | TH9203962 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| H.S.code* | 2933.59-000 |
Application
Olaparib: An Inhibitor of Poly(ADP-ribose) Polymerase (PARP) Enzymes
Poly(ADP-ribose) polymerase (PARP) enzymes, including PARP1, PARP2, and PARP3, play a role in normal cellular functions such as DNA transcription and repair of single-strand DNA breaks. Inhibition of PARPs alone is not lethal because DNA lesions can be repaired by other DNA repair pathways, specifically homologous recombination repair (HRR). Conversely, BRCA1 and BRCA2 proteins are crucial for the accurate repair of double-strand DNA breaks through the HRR pathway. Consequently, cancer cells deficient in BRCA1 and BRCA2 are hypersensitive to PARP inhibitors. Olaparib inhibits PARPs and has been shown to inhibit the growth of select cancer cell lines in vivo and in vitro. In vitro studies have demonstrated that olaparib-induced cytotoxicity may involve inhibition of PARP enzymatic activity and increases the formation of PARP-DNA complexes, resulting in DNA damage and cancer cell death. (The product is for research use only.)
References
- Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors
- Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
- Targeting the DNA Damage Response in Cancer (a review)
- A decade of clinical development of PARP inhibitors in perspective (a review)
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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