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CAS RN: 950762-95-5 | Product Number: P3226
PCI-34051
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Purity: >95.0%(HPLC)(qNMR)
Synonyms:
- N-Hydroxy-1-(4-methoxybenzyl)-1H-indole-6-carboxamide
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 10MG |
$137.00
|
12 | 0 | Contact Us | |
| 50MG |
$482.00
|
12 | 0 | Contact Us |
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to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.
| Product Number | P3226 |
Purity / Analysis Method 
|
>95.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__1__7H__1__6N__2O__3 = 296.33 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 950762-95-5 |
| Reaxys Registry Number | 11340810 |
| MDL Number | MFCD11114393 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(qNMR) | min. 95.0 % |
| Melting point | 155.0 to 159.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 157 °C |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2933.99-000 |
Application
PCI-34051: An HDAC8-Specific Inhibitor
Recent studies have shown that histone deacetylase 8 (HDAC8) regulates the expression and activity of genes involved in cancer initiation and progression.1) Therefore, HDAC8 is a promising target in cancer research. PCI-34051, an HDAC8-specific inhibitor, has been used in such research.2,3) (The product is for research use only.)
References
- 1) The clinical significance of histone deacetylase-8 in human breast cancer (a review)
- 2) A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas
- 3) An Unbiased Approach To Identify Endogenous Substrates of "Histone" Deacetylase 8
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