Recently, mRNA medicines have received a lot of attention, which generate the specific proteins in the target cells. Application of mRNA medicines are expected for not only vaccine but also protein replacement therapy, regenerative medicine, and gene editing therapy by expression antigens, enzymes, signal proteins and more. In translation of mRNA into protein in target cell, 1-methylpseudouridine (m1Ψ) and pseudouridine (Ψ) are read like uridine (U), enhancing immune evasion and protein production. Because of this, 1-methylpseudouridine and pseudouridine are essential components for the development of mRNA medicine.
TCI offers 1-methylpseudouridine and pseudouridine by chemical synthesis, and can also supply these products in bulk quantities or synthesize the derivatives.
- 1) N1-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice
- 2) Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines