Start > Ausstellungen / Broschüren > Quarterly Printed Magazine "TCIMAIL" > Back Numbers > Bone Resorption Inhibitor

Bone Resorption Inhibitor

No.159(October 2013)
D4167
Disodium Tiludronate  (1)
Bisphosphonates (BPs), including alendronate, ibandronate, etc., are very effective inhibitors of bone resorption in vivo and in vitro. Disodium tiludronate (1) is one of the BPs. These compounds are characterized by two C-P bonds which are located on the same carbon atom, i.e. geminal BPs, and have been used in many research projects regarding bone metabolism.
According to differences in the side chain, BPs can be divided into two groups, non-nitrogen containing BPs and nitrogen-containing BPs. The former can be metabolized to methylene-containing analogues of ATP (AppCp) and the metabolite causes osteoclast cell death. The latter can inhibit farnesyl pyrophosphate synthetase in the mevalonate biosynthetic pathway. 1 is a non-nitrogen containing BP and compound 2 is the AppCp from 1. For detailed information, please refer to the following references.1-5)

References

The prices are subject to change without notice. Please confirm the newest price by our online catalog before placing an order.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.