03/31/2014  TCI NEWS

We distribute TCI NEWS every four weeks, to our valued customers using research chemicals and chromatography products.
We hope that you find this helpful for your research.

[NEW] TCI Catalog 2014-2015 - Includes 1,500 New Products

RequestCatalog
The new catalog includes over 23,000 research chemicals, with 1,500 new products for synthetic organic chemistry, materials chemistry, bioscience and analytical science.  The catalog also contains chemical structure formulas, extensive physical and chemical data, and hazard information, etc.

[NEW] TCIMAIL No.161 - Paper Magazine

In the TCIMAIL, we mainly introduce our new reagents in the fields of Synthetic Organic Chemistry, Materials Chemistry, Bioscience and Analytical Science.  Examples of application and use are explained in an easy to understand way, using various schemes and charts.  The TCIMAIL also contains technical papers contributed by leading professors and scientists.

TCIMAIL No.161 April 2014

TCI Mail No.161

Chemistry Chat
Focusing on the Elements - Colors and Chemical Names (2)
Kentaro Sato
Visit to a School Science Lab - Chemistry Club at Komaba Toho Junior and Senior High School

Applications
- Efficient Bis(oxazolidine)pyridine Ligands Utilized for the Asymmetric [3+2] Cycloaddition
- Heteroarenesulfonyl Cinchona Alkaloid Amine Catalyst
- A Convenient Gold(I) Complex Used for the Preparation of Cationic Gold(I) Complexes
- A Convenient Nucleophilic Iodinating Reagent
- Multidentate Ligand for Atom Transfer Radical Polymerization
- NO Detection Reagent
- p53 Inhibitors
- Plant Bitter Ingredient

Synthetic Organic Chemistry

Research Article

A Novel Hydroxy Protecting Group: Sulfonylcarbamate Group

Manabe et al. have developed the sulfonylcarbamate group as a novel hydroxy protecting group and reported its utility. According to their results, the sulfonylcarbamate group can easily be introduced by the reaction of alcohols with p-toluenesulfonyl isocyanate under neutral conditions. This protecting group has the unique property that it is completely stable under strongly basic conditions, while it can be deprotected under extremely mild basic conditions such as in pyridine-MeOH. Furthermore, the deprotection can be achieved under strongly basic conditions after alkylation at the nitrogen atom of the carbamate group. Since this protection-deprotection reaction is carried out under mild conditions with operational simplicity, it can be applied to a wide range of substrates.
T0998

References

S. Manabe, M. Yamaguchi, Y. Ito, Chem. Commun. 2013, 49, 8332.

New Products

Bioscience

Product Highlight

An Antibiotic Substance in Cordyceps sinensis

Cordyceps is a genus of fungi which are parasitic in insects. Cordyceps sinensis germinating in larvae of ghost moths, and Cordyceps militaris parasitizing lepidopterous larvae have been used for traditional Chinese medicine. Cordycepin (cordycepin hydrate) (1), one of the bioactive components in Cordyceps, has a chemical structure similar to that of adenosine. Therefore, 1 shows antitumor effects because of its inhibitory activity against RNA polyadenylation, etc.3-6) Furthermore, an insecticidal effect7) and an antibacterial effect8) of 1 have been reported also.
C2689, C2815

References

1) T. B. Ng, H. X. Wang, J. Pharm. Pharmacol. 2005, 57, 1509.
2) X. Zhou, Z. Gong, Y. Su, J. Lin, K. Tang, J. Pharm. Pharmacol. 2009, 61, 279.
3) N. Yoshikawa, K. Nakamura, Y. Yamaguchi, S. Kagota, K. Shinozuka, M. Kunitomo, Clin. Exp. Pharmacol. Physiol. 2004, 31, S51.
4) K. Nakamura, N. Yoshikawa, Y. Yamaguchi, S. Kagota, K. Shinozuka, M. Kunitomo, Anticancer Res. 2006, 26, 43.
5) W.-C. Wu, J.-R. Hsiao, Y.-Y. Lian, C.-Y. Lin, B.-M. Huang, Cancer Chemother. Pharmacol. 2007, 60, 103.
6) L. S. Chen, C. M. Stellrecht, V. Gandhi, Br. J. Haematol. 2008, 140, 682.
7) J.-R. Kim, S.-H. Yeon, H.-S. Kim, Y.-J. Ahn, Pest Management Sci. 2002, 58, 713.
8) Y.-J. Ahn, S.-J. Park, S.-G. Lee, S.-C. Shin, D.-H. Choi, J. Agric. Food Chem. 2000, 48, 2744.

New Products

Chromatography

HPLC Chiral columns “TCI Chiral series”

•A unique stationary phase
  Polymaleimide (helical polymer) bearing chiral side groups coated on silica gel.
•Suitable for separation of carbonyl and other compounds
  ex. Ketones, Esters, Carboxylic acids, N-Protected Amino acids, Alcohols etc.
• High column load capacity
• Superior column longevity
  Maximum pressure: 2900 psi (20 MPa)
•Affordable price

» TCI Chiral series information

This compound can be analyzed without using derivatization reagents, and high-throughput analysis is possible.

» Details of this application

TCI Website Tips

TCI Catalogs & Product Brochures

TCI has a wide variety of specific catalogs and product brochures. Most of them are available in PDF format and can be downloaded from our website.
Please click the following links to pick up the catalogs and brochures you are interested in:

Regional Campaigns, Events & Exhibitions

Singapore
Buy 3 TCI Reagents, Get a FREE Foldable Water Bottle! (March 1, 2014 - April 30, 2014)

» Click for campaign details



Australia
AUD prices -Available from November 25, 2013

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