04/28/2014  TCI NEWS

We distribute TCI NEWS every four weeks, to our valued customers using research chemicals and chromatography products.
We hope that you find this helpful for your research.

[NEW] TCI Catalog 2014-2015 - Includes 1,500 New Products

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The new catalog includes over 23,000 research chemicals, with 1,500 new products for synthetic organic chemistry, materials chemistry, bioscience and analytical science.  The catalog also contains chemical structure formulas, extensive physical and chemical data, and hazard information, etc.

[NEW] TCIMAIL No.161 - Paper Magazine

In the TCIMAIL, we mainly introduce our new reagents in the fields of Synthetic Organic Chemistry, Materials Chemistry, Bioscience and Analytical Science.  Examples of application and use are explained in an easy to understand way, using various schemes and charts.  The TCIMAIL also contains technical papers contributed by leading professors and scientists.

TCIMAIL No.161 April 2014

TCI Mail No.161

Chemistry Chat
Focusing on the Elements - Colors and Chemical Names (2)
Kentaro Sato
Visit to a School Science Lab - Chemistry Club at Komaba Toho Junior and Senior High School

Applications
- Efficient Bis(oxazolidine)pyridine Ligands Utilized for the Asymmetric [3+2] Cycloaddition
- Heteroarenesulfonyl Cinchona Alkaloid Amine Catalyst
- A Convenient Gold(I) Complex Used for the Preparation of Cationic Gold(I) Complexes
- A Convenient Nucleophilic Iodinating Reagent
- Multidentate Ligand for Atom Transfer Radical Polymerization
- NO Detection Reagent
- p53 Inhibitors
- Plant Bitter Ingredient

Synthetic Organic Chemistry

Research Article

Pd-Catalyzed Z-Selective Oxidative Amination of Olefins

Obora et al. have reported the Pd-catalyzed Z-selective oxidative amination of olefins. According to their results, the palladium(II) acetate-catalyzed aerobic oxidative amination of olefins with ortho-substituted primary anilines successfully proceeds under the presence of pivalic acid as an additive, and the corresponding N-alkenyl anilines are given in high yields. This reaction does not need an external reoxidant, and the products have unusually high level of Z-selectivity.
P0461

References

Y. Mizuta, K. Yasuda, Y. Obora, J. Org. Chem. 2013, 78, 6332.

New Products

Bioscience

Product Highlight

A Bioconjugatable Linker having a Copper-free "Click" Reaction to Azides

Huisgen [3+2] cycloaddition of azides with terminal alkynes is representative of "Click Chemistry" described by K. B. Sharpless in 2001. The reaction which affords products in high yield has been used for imaging labeling and tracking labeling of biomolecules. However, the reaction is not suitable for labeling of living systems because it needs a highly-concentrated copper(I) species.1)
BCN-amine (1) is a linker having a strained structure with cyclooctyne, and it is used for the copper-free click reaction to azides. For example, 1 bonded to a fluorophore (2) has resulted in labeling of an azidohomoalanine-containing virus capsid protein without copper(I) species.2) In addition, 1 can be applied to not only strain-promoted alkyne-azide cycloaddition (SPAAC)3) but also strain-promoted alkyne-nitrone cycloaddition (SPANC).4)
B4062

References

1) J.-F. Lutz, Angew. Chem. Int. Ed. 2008, 47, 2182.
2) J. Dommerholt, S. Schmidt, R. Temming, L. J. A. Hendriks, F. P. J. T. Rutjes, J. C. M. van Hest, D. J. Lefeber, P. Friedl,
   F. L. van Delft, Angew. Chem. Int. Ed. 2010, 49, 9422.
3) N. J. Agard, J. A. Prescher, C. R. Bertozzi, J. Am. Chem. Soc. 2004, 126, 15046.
4) X. Ning, R. P. Temming, J. Dommerholt, J. Guo, D. B. Ania, M. F. Debets, M. A. Wolfert, G.-J. Boons, F. L. van Delft,
   Angew. Chem. Int. Ed. 2010, 49, 3065.

New Products

Chromatography

HPLC Mixed-Mode columns “TCI Dual”

•Hydrophilic compounds can be retained on mix-mode columns
•also can be retained
•No ion-pair reagent is required

Target compound is basic : Choose ODS + Cation-Exchange Type
    TCI Dual ODS-CX10 / TCI Dual ODS-CX15 / TCI Dual ODS-CX20
Target compound is acidic : Choose ODS + Anion-Exchange Type
    TCI Dual ODS-AX20 / TCI Dual ODS-AX10 / Kaseisorb LC ODS-SAX Super

» TCI Dual product information and applications


                                        Analysis of N-Acetylneuramic acid by TCI Dual

TCI Website Tips

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Regional Campaigns, Events & Exhibitions

Singapore
Buy 3 TCI Reagents, Get a FREE Foldable Water Bottle! (March 1, 2014 - April 30, 2014)

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Australia
AUD prices -Available from November 25, 2013

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