06/02/2014  TCI NEWS

We distribute TCI NEWS every four weeks, to our valued customers using research chemicals and chromatography products.
We hope that you find this helpful for your research.

[NEW] Pamphlet - Alkylation Reagents for Ester Synthesis

Pamphlet
TCI now published new pamphlet that collected alkylation reagents for ester synthesis.

Classified by alkyl chains - easy to find desired products
Unique alkylation reagents are also included
Can be easily check the product information in our website by clicking on the chemical structures in the product list

TCI Catalogs & Product Brochures

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TCI has a wide variety of specific catalogs and product brochures. Most of them are available in PDF format and can be downloaded from our website.
Please click the following links to pick up the catalogs and brochures you are interested in:

Synthetic Organic Chemistry

Research Article

A Mild Ethynylating Reagent

1-[(Triisopropylsilyl)ethynyl]-1,2-benziodoxol-3(1H)-one (=TIPS-EBX) is a mild ethynylating reagent and well used for site-selective ethynylations. For example, a palladium catalyzed ethynylation of indoles proceeds at C2-selectively, while complementary C3-selective ethynylation is accomplished by using gold chloride as a catalyst. Gold catalyst-promoted site selective ethynylations are applied to thiophenes and N,N-dialkyl anilines affording C2-ethynylated thiophenes and para- ethynylated anilines. A TIPS group on the alkynes can be easily removed under basic conditions and affords related terminal alkynes. Thus, TIPS-EBX is an efficient ethynylating reagent applicable for click chemistry and material sciences.
T3039

References

1) J. P. Brand, J. Waser, Synthesis 2012, 44, 1155.
2) G. L. Tolnai, S. Ganss, J. P. Brand, J. Waser, Org. Lett. 2013, 15, 112.
3) J. P. Brand, J. Charpentier, J. Waser, Angew. Chem. Int. Ed. 2009, 48, 9346.
4) J. P. Brand, J. Waser, Angew. Chem. Int. Ed. 2010, 49, 7304.
5) J. P. Brand, J. Waser, Org. Lett. 2012, 14, 744.

New Products

Bioscience

Product Highlight

The Sixth Nucleoside of the Genome, 5-hmdC

2'-Deoxy-5-(hydroxymethyl)cytidine (5-hmdC) and its base 5-hydroxymethylcytosine (5-hmC) were recently discovered as oxidation products of 2’-deoxy-5-methylcytidine (5-mdC) in mammalian DNA, particularly in stem cell DNA. 5-mdC, a C5-methylated form of 2'-deoxycytidine (dC), has been studied as an indicator of DNA methylation in epigenetics. On the other hand, the biological function of 5-hmdC is currently not clear, but it is assumed that in stem cells it might be an intermediate of an active de-methylation process. Detection of 5-hmdC in a genome has been investigated to elucidate its role.
D4220

References

1) T. Pfaffeneder, B. Hackner, M. Truß, M. Münzel, M. Müller, C. A. Deiml, C. Hagemeier, T. Carell, Angew. Chem. Int. Ed. 2011, 50, 7008.
2) M. Münzel, D. Globisch, T. Carell, Angew. Chem. Int. Ed. 2011, 50, 6460.
3) S.-G. Jin, Y. Jiang, R. Qiu, T. A. Rauch, Y. Wang, G. Schackert, D. Krex, Q. Lu, G. P. Pfeifer, Cancer Res. 2011, 71, 7360.
4) A. M. Krais, Y. J. Park, C. Plass, H. H. Schmeiser, Epigenetics 2011, 6, 560.
5) J. Hu, Y. Chen, X. Xu, F. Wu, X. Xing, Z. Xu, J. Xu, X. Weng, X. Zhou, Bioorg. Med. Chem. Lett. 2014, 24, 294.
6) S. Schiesser, T. Pfaffeneder, K. Sadeghian, B. Hackner, B. Steigenberger, A. S. Schröder, J. Steinbacher, G. Kashiwazaki, G. Höfner, K. T. Wanner, C. Ochsenfeld, T. Carell, J. Am. Chem. Soc. 2013, 135, 14593.

New Products

Chromatography

HPLC Mixed-Mode columns “TCI Dual”

•Hydrophilic compounds can be retained on mix-mode columns
•also can be retained
•No ion-pair reagent is required

Target compound is basic : Choose ODS + Cation-Exchange Type
    TCI Dual ODS-CX10 / TCI Dual ODS-CX15 / TCI Dual ODS-CX20
Target compound is acidic : Choose ODS + Anion-Exchange Type
    TCI Dual ODS-AX20 / TCI Dual ODS-AX10 / Kaseisorb LC ODS-SAX Super

» Technical information and applications of TCI Dual products


TCIDUal
                                        Analysis of N-Acetylneuramic acid by TCI Dual

TCI Website Tips

About TCI -Get to know TCI

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You want to know TCI more, please move the mouse cursor on "About TCI" and choose each category. You can watch TCI company video as well as 120 years company history, our product scope, and more.
Also you can find the location of TCI global offices and manufacturing plants, R&D centers, Distribution centers and more.

Exhibitions/Meetings/Shows

VIC Polymer Technologies Workshop

Monash Institute of Pharmaceutical Sciences (MIPS)
Victoria, Australia
June 26-27, 2014
» TCI exhibition information      » Event details

4th International Conference on Hypervalent Iodine Chemistry (ICHIC2014)

Hilton Narita
Narita, Chiba, Japan
July 2-5, 2014
» TCI exhibition information      » Event details

XXVI International Conference on Organometallic Chemistry (ICOMC 2014)

Royton Sapporo (Hotel)
Sapporo, Hokkaido, Japan
July 13-18
» TCI exhibition information      » Event details

Other Information

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