07/28/2014  TCI NEWS

We distribute TCI NEWS every four weeks, to our valued customers using research chemicals and chromatography products.
We hope that you find this helpful for your research.

Product Brochure – Ion-Pair Reagents for HPLC

Recently, reversed phase partition chromatography using ion-pair reagents has been developed and utilized. The ionic samples form an ion-pair with ion-pair reagents in the mobile phase to become electrically neutral. The increase in hydrophobic character of the ion-pair results in a greater affinity for the reverse stationary phase and leads to sample resolution. TCI provides wide variety of ion-pair reagents. These qualities are placed strict control, then we believe they will satisfy you.
Here are the typical product groups;

HPLC Ion-Pair Reagents for Acidic Samples
LC/MS Ion-Pair Reagents for Acidic Samples
HPLC Ion-Pair Reagents for Basic Samples
LC/MS Ion-Pair Reagents for Basic Samples
Fluorimetric Ion-Pair Reagent for HPLC

Chromatography -Latest Application of TCI HPLC Columns

Analysis of L-Ascorbic acid related compounds by TCI Dual series

TCIDUal
L-Ascorbic acid related compounds having high hydrophilicity can be analyzed without ion-pair reagents. It can also applied to LC/MS, because these compounds are analyzed with using volatile buffer.

Synthetic Organic Chemistry

Research Article

An Epoxidation of Alkenes using H2O2 (aq.) and 2,2,2-Trifluoroacetophenone

Limnios and Kokotos have reported the environmentally friendly epoxidation of alkenes using 2,2,2-trifluoroacetophenone as an organocatalyst in combination with a green oxidant aqueous H2O2. Various olefins are epoxidized chemoselectively in high to quantitative yields utilizing 2-5 mol% of the organocatalyst loading in acetonitrile and tert-butyl alcohol.
T0848

References

D. Limnios, C. G. Kokotos, J. Org. Chem. 2014, 79, 4270.

New Products

Bioscience

Product Highlight

An Inhibitor against NF-κB, a Significant Transcription Factor in the Immune System

NF-κB (nuclear factor kappa B) is an intracellular protein complex that controls gene transcription, which was identified by D. Baltimore et al. in 1986.1) NF-κB is usually sequestered in the cytoplasm by forming an inactivated complex with IκB (Inhibitor κB). IKK (IκB kinase) activated by extracellular signals phosphorylates IκBα, and then the proteasome degrades phosphorylated IκBα. Then NF-κB can translocate into the nucleus and induce the expression of genes encoding molecules related to inflammatory immune response, apoptosis-suppressing molecules, cytostatic molecules, etc.2)
BAY 11-7082 is a small molecule inhibiting the phosphorylation of IκBα by IKK.3) It has been reported to use BAY 11-7082 as a NF-κB inhibitor in research of cancer, inflammation, viral infection and so on.4-7)
T2846

References

1) R. Sen, D. Baltimore, Cell 1986, 47, 921.
2) B. Hoesel, J. A Schmid, Mol. Cancer 2013, 12, 86.
3) J. W. Pierce, R. Schoenleber, G. Jesmok, J. Best, S. A. Moore, T. Collins, M. E. Gerritsen, J. Biol. Chem. 1997, 272, 21096.
4) N. Mori, Y. Yamada, S. Ikeda, Y. Yamasaki, K. Tsukasaki, Y. Tanaka, M. Tomonaga, N. Yamamoto, M. Fujii, Blood 2002, 100, 1828.
5) C. Nakanishi, M. Toi, Nat. Rev. Cancer 2005, 5, 297.
6) C. Juliana, T. Fernandes-Alnemri, J. Wu, P. Datta, L. Solorzano, J.-W. Yu, R. Meng, A. A. Quong, E. Latz, C. P. Scott, E. S. Alnemri, J. Biol. Chem. 2010, 285, 9792.
7) C. Higashi, C. Saji, K. Yamada, H. Kagawa, R. Ohga, T. Taira, M. Fujimuro, Biol. Pharm. Bull. 2012, 35, 725.

New Products

TCI Catalogs & Product Brochures

websitetip
TCI has a wide variety of specific catalogs and product brochures. Most of them are available in PDF format and can be downloaded from our website.
Please click the following links to pick up the catalogs and brochures you are interested in:

TCI Website Tips

Reagent Guide Online –Product Information Page in TCI Website

TCI Reagent Guides, product catalogs by category, are very useful as reference book for finding reagents. Do you know Reagent Guides are available as online version in our website?
You click “Products” tab, then you can go around our product information by category easily.

Additionally, there are many online version specific features;
-New products that aren’t included in Reagent Guide are added every day.
-Product categories that aren’t included in Reagent Guides are available, and new categories are uploaded on a timely basis.

Please click the following product categories, and find your chemicals!

Exhibitions/Meetings/Shows

248th ACS National Meeting & Exposition

San Francisco, California
Moscone Center
Booth# 1300
August 10-14, 2014
» TCI exhibition information      » Event details

Sialoglyco 2014

Gold Coast, Australia
Sept. 7-10, 2014
» TCI exhibition information      » Event details

Other Information

TCI Facebook Page

logo Various chemistry related information, news, and fun content are posted for you.  Visit us and like us on Facebook!

https://www.facebook.com/TCIchemicals

How to Order TCI Products

For order, please contact our local distributors as follow.

Countries/ Regions:

Singapore

Taiwan

Australia

South Korea

Hong Kong

Other Asia Pacific / Regions


* The prices displayed in the landing website are USD based catalog prices.  TCI has specific website and local currency based price list for customers in South Korea, Singapore, and Australia.  For customers in other Asia Pacific countries / regions, please visit our Asia Pacific Website and contact our local distributors for the end user's cost. (The USD prices that are shown in Asia Pacific websites are TCI's catalog prices.)
Please visit each country/region's website from the following links and confirm the prices.


http://www.tcichemicals.com

TCI has sent this enewsletter to you at the following address:
<{!Lead.Email}>

This enewsletter is delivered to our customers who request TCI's information or exchange business cards, etc.
Please check the following information about how to change delivery address and unsubscribe the enewsletter.
It will take some time to complete changing your status. Thank you for your patience and understanding.

●MyTCI Member
Please log in to MyTCI and edit your account information. "Edit Your Account Information" button is in the upper right in MyTCI page.

» Log in to MyTCI

●non-MyTCI Member
If you wish to change your email address, please reply email to us with "Change Contact" as the subject. Don't remove the above mentioned email address that was used to send this enewsletter.
Please note that we will not be able to give effect to the change or unsubscribe request if the email address that you enter in the reply email is different from the email address referenced above that was used by TCI to send this enewsletter.


To unsubscribe from future mailings, please email us with "Unsubscribe" as the subject to the address below.

» TCIeNewsletter@TCIchemicals.com

Tokyo Chemical Industry Co., Ltd.
4-10-2 Nihonbashi-honcho, Chuo-ku,
Tokyo 103-0023

» TCIeNewsletter@TCIchemicals.com

» http://www.TCIchemicals.com