08/25/2014  TCI NEWS

We distribute TCI NEWS every four weeks, to our valued customers using research chemicals and chromatography products.
We hope that you find this helpful for your research.

[NEW] TCIMAIL No.162 - Quarterly Magazine

In the TCIMAIL, we mainly introduce our new reagents in the fields of Synthetic Organic Chemistry, Materials Chemistry, Bioscience and Analytical Science.  Examples of application and use are explained in an easy to understand way, using various schemes and charts.  The TCIMAIL also contains technical papers contributed by leading professors and scientists.
TCI Mail No.162

Chemistry Chat
Focusing on the Elements - Molecular Regular Polygons
Mr. Kentaro Sato

Applications
- Useful Cinchona Alkaloid Derived Catalysts
- A Building Block for Organic Electronic Material Incorporating A Reactive 1,2-Diketone Moiety Forming Tetracene Derivatives
- An Ambipolar Organic Semiconductor with Well-Balanced High Hole and Electron Mobility
- Solubility-improved Organic Semiconductor, Thiophene/Phenylene Co-oligomer (TPCO)
- ABBX, A Highly Active Trivalent Iodine Compound for Oxidation Reactions
- γ-Secretase Inhibitor
- Sonic Hedgehog Inhibitor
- Cell Differentiation Research Reagent
- Bone Resorption Inhibitor

Reagents for Glyco Chemistry & Biology, 4th Edition

 Total of 700 products including 100 new products and
 1H NMR spectral data of 170 products.


 - Described in detail about newly-marketed anti-glyco antibodies.
 - A large number of functional oligosaccharides involved in cancer,
 inflammation and immunity.
 - Oligosaccharides having a linker or functional group, which can be
 applied to sugar-conjugates.
 - Glycosynthase, lectin, and a wide variety of building blocks.

TCI will attend Sialoglyco 2014 as an Exhibitor. This will be held from Sept.7 to 10th, in Gold Coast, Australia.
TCI Technical Engineers and Sales Reps. are looking forward to seeing you there!!

Synthetic Organic Chemistry

Research Article

Stereoinversion of tertiary alcohols to tertiary-alkyl isonitriles

Shenvi et al. have reported a stereochemical inversion of tertiary alcohols to tertiary alkylisonitriles and amine. In this report, tertiary alkylisonitriles are given from the corresponding tertiary alcohols with inversion of chirality by the trifluoroacetylation of the starting alcohol’s subsequent Sc(OTf)3 catalyzed reaction with an excess amount of TMSCN. This reaction is chemoselective for tertiary-alcohols in preference to primary or secondary ones, opposite to the SN2 reaction, thereby complementing the selectivity of the Mitsunobu reaction.
T1663

References

S. V. Pronin, C. A. Reiher, R. A. Shenvi, Nature 2013, 501, 195.

New Products

Bioscience

Product Highlight

A Bioactive Polyphenol in Hops and Beer

Hops (Humulus lupulus) includes not only bitter and aroma components but also some polyphenols. Xanthohumol, a kind of polyphenol, has a structure of prenylchalcone and shows various bioactivities.1,2) For example, the activities have been reported as an antiproliferative activity of cancer,3) a chemopreventive activity,4) a bone resorption inhibition activity,5) an antioxidative activity,6) a diacylglycerol acyltransferase (DGAT, an enzyme related to lipogenesis) inhibition activity7) and so on.
X0068

References

1) J. F. Stevens, J. E. Page, Phytochemistry 2004, 65, 1317.
2) P. Zanoli, M. Zavatti, J. Ethnopharmacol. 2008, 116, 383.
3) C. L. Miranda, J. F. Stevens, A. Helmrich, M. C. Henderson, R. J. Rodriguez, Y.-H. Yang, M. L. Deinzer, D. W. Barnes, D. R. Buhler, Food Chem. Toxicol. 1999, 37, 271.
4) C. Gerhauser, A. Alt, E. Heiss, A. Gamal-Eldeen, K. Klimo, J. Knauft, I. Neumann, H. Scherf, N. Frank, H. Bartsch, H. Becker, Mol. Cancer Ther. 2002, 1, 959.
5) H. Tobe, Y. Muraki, K. Kitamura, O. Komiyama, Y. Sato, T. Sugioka, H. B. Maruyama, E. Matsuda, M. Nagai, Biosci. Biotechnol. Biochem. 1997, 61, 158.
6) C. L. Miranda, J. F. Stevens, V. Ivanov, M. McCall, B. Frei, M. L. Deinzer, D. R. Buhler, J. Agric. Food Chem. 2000, 48, 3876.
7) N. Tabata, M. Ito, H. Tomoda, S. Omura, Phytochemistry 1997, 46, 683.

New Products

Chromatography -Latest Application of TCI HPLC Columns

TCIDUal
With our TCI ODS-AX20, highly hydrophilic molecules such as L-Ascorbic acid and related compounds can be analyzed without ion-pair reagents. This application can also be performed by LC-MS with a volatile buffer.

TCI Catalogs & Product Brochures

websitetip
TCI has a wide variety of specific catalogs and product brochures. Most of them are available in PDF format and can be downloaded from our website.
Please click the following links to pick up the catalogs and brochures you are interested in:

TCI Website Tips

Reagent Guide Online –Product Information Page in TCI Website

TCI Reagent Guides, product catalogs by category, are very useful as reference book for finding reagents. Do you know Reagent Guides are available as online version in our website?
You click “Products” tab, then you can go around our product information by category easily.

Additionally, there are many online version specific features;
-New products that aren’t included in Reagent Guide are added every day.
-Product categories that aren’t included in Reagent Guides are available, and new categories are uploaded on a timely basis.

Please click the following product categories, and find your chemicals!

Exhibitions/Meetings/Shows

JASIS 2014

Booth# 4B-003
Makuhari Messe
Chiba City, Chiba, Japan
September 3-5, 2014
» TCI exhibition information      » Event details

Sialoglyco 2014

Gold Coast, Australia
Sept. 7-10, 2014
» TCI exhibition information      » Event details

Other Information

TCI Facebook Page

logo Various chemistry related information, news, and fun content are posted for you.  Visit us and like us on Facebook!

https://www.facebook.com/TCIchemicals

How to Order TCI Products

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Please visit each country/region's website from the following links and confirm the prices.


http://www.tcichemicals.com

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