10/20/2014  TCI NEWS

We distribute TCI NEWS every four weeks, to our valued customers using research chemicals and chromatography products.
We hope that you find this helpful for your research.

Product Brochure – Antimicrobials & Antitumors for Research and Experimental Use

Antimicrobials are chemical substances inhibiting growth of microorganisms, namely microbial, fungal and viral. Antitumors act by inhibiting the growth of tumor cells. Some of them such as geldanamycin have both antibacterial and antitumor activities. In addition, antimicrobials has been used in molecular biology as a reagent for selection of bacteria.
Here are the typical product groups;

Antibiotics
Synthetic Antimicrobials
Antifungals
Antivirals
Antitumors

Product Brochure – Pharmaceutical Ingredients for Research and Experimental Use

Pharmaceutical ingredients are the substances that have biologically activities in pharmaceuticals. They are used as the comparative compounds in drug development, inhibitors in molecular biology, and reference materials in analytical science.
Here are the typical product groups;

Antihypertensive Ingredients
Antilipemic Ingredients
Antidiabetic Ingredients
Anti-inflammatory Ingredients
Anti-allergic Ingredients

New Chiral Phosphine Ligands and Ruthenium Catalysts

TCI provides new ligands and catalysts for asymmetric synthesis. Especially, new ruthenium catalysts, for example R0138, are effective for asymmetric reduction of ketones. For more details, please click on the link below to refer the product list and brochures.

TCI Mobile


TCI mobile website now available on smartphones and tablets!

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Access to http://www.tcichemicals.com/en/ap/ on your mobile

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Synthetic Organic Chemistry

Product Highlight

Useful and Air-Stable Zinc(II) Chloride Equivalent

Dichloro(N,N,N',N'-tetramethylethane-1,2-diamine)zinc(II) (1) is a zinc complex coordinated by N,N,N',N'-tetramethylethylenediamine (TMEDA). Zinc(II) dichloride (ZnCl2) is commonly used for the preparation of organozinc reagents. However, prepared organozinc species are partly decomposed due to hygroscopicity and the dissolution of ZnCl2 to THF and ether solvents being exothermic. Therefore, commercially available THF or ether solutions of ZnCl2 should be carefully handled after opening. On the other hand, 1 is air-stable and non-hygroscopic with easier handling and storage compared to that of ZnCl2. 1 can be used for the preparation of organozinc species without hygroscopic decomposition. Now, 1 is applied to the synthesis of silole derivatives.
D4393

References

R. A. Kjonaas, R. K. Hoffer, J. Org. Chem. 1988, 53, 4133.
I. Mutule, E. Suna, Tetrahedron 2005, 61, 11168.
A. Seggio, A. Jutand, G. Priem, F. Mongin, Synlett 2008, 2955.
F. Chevallier, M. Charlot, C. Katan, F. Mongin, M. Blanchard-Desce, Chem. Commun. 2009, 692.
Z. Zhao, Z. Wang, P. Lu, C. Y. K. Chan, D. Liu, J. W. Y. Lam, H. H. Y. Sung, I. D. Williams, Y. Ma, B. Z. Tang, Angew. Chem. Int. Ed. 2009, 48, 7608.

New Products

Bioscience

Research Article

Metformin Shows an Antidiabetic Effect by Regulating Lipid Metabolism via AMPK-ACC Pathway

Metformin (1) is a widely-used antidiabetic ingredient for type 2 diabetes with no defined cellular mechanism of its action. Its efficacy has been considered to be due to the activation of AMP-activated protein kinase (AMPK) which is a major cellular regulator of lipid and glucose metabolism.
AMPK phosphorylates mouse acetyl-CoA carboxylase 1 (ACC1) at Ser79 and acetyl-CoA carboxylase 2 (ACC2) at Ser212, inactivating these enzymes. As the conversion of acetyl-CoA to malonyl-CoA by these enzymes is inhibited, subsequent lipid metabolism is regulated.
Therefore, Steinberg et al. generated mice with double-knock-in mutations in both ACC1 (Ser79Ala) and ACC2 (Ser212Ala) in order to investigate the mechanism of 1. As a result, they have reported that inhibitory phosphorylation of ACC1 and ACC2 by 1-activated AMPK is critical for controlling lipid metabolism, and the control may contribute to the improvement of insulin-resistance in obese mice.
M2009

References

M. D. Fullerton, S. Galic, K. Marcinko, S. Sikkema, T. Pulinilkunnil, Z.-P. Chen, H. M. O'Neill, R. J. Ford, R. Palanivel, M. O'Brien, D. G. Hardie, S. L. Macaulay, J. D. Schertzer, J. R. B. Dyck, B. J. van Denderen, B. E. Kemp, G. R. Steinberg, Nat. Med. 2013, 19, 1649.

New Products

Chromatography -Analysis of Tranexamic acid by TCI Dual series

TCIDUal
Tranexamic acid is an amino acid analog with high hydrophilicity. However, with TCI Dual series, successful separation can be performed easily without any ion-pair reagents.
This application is also suitable for LC-MS by using volatile buffers.

TCI Catalogs & Product Brochures

websitetip
TCI has a wide variety of specific catalogs and product brochures. Most of them are available in PDF format and can be downloaded from our website.
Please click the following links to pick up the catalogs and brochures you are interested in:

TCI Website Tips

Reagent Guide Online –Product Information Page in TCI Website

TCI Reagent Guides, product catalogs by category, are very useful as reference book for finding reagents. Do you know Reagent Guides are available as online version in our website?
You click “Products” tab, then you can go around our product information by category easily.

Additionally, there are many online version specific features;
-New products that aren’t included in Reagent Guide are added every day.
-Product categories that aren’t included in Reagent Guides are available, and new categories are uploaded on a timely basis.

Please click the following product categories, and find your chemicals!

Exhibitions/Meetings/Shows

2014 RACI National Congress
Adelaide Convention Centre
Adelaide, Australia
December 7-12, 2014
» TCI exhibition information      » Event details
8th Singapore International Chemistry Conference 2014
National University of Singapore
Singapore
December 14-17, 2014
» TCI exhibition information      » Event details

Other Information

TCI Facebook Page

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How to Order TCI Products

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Please visit each country/region's website from the following links and confirm the prices.


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