2/9/2015  TCI NEWS

We distribute TCI NEWS every four weeks, to our valued customers using research chemicals and chromatography products. We hope that you find this helpful for your research.

Contents Highlights

Synthetic Organic Chemistry

Research Article

Catalytic Trifluoromethylthiolation Using N-(Trifluoromethylthio)phthalimide

Rueping et al. have reported the catalytic trifluoromethylthiolation using N-(trifluoromethylthio)phthalimide (1). According to their results, 1 acts as an electrophilic source of CF3S+, and readily reacts with boronic acids and terminal alkynes under copper catalysis to afford the corresponding CF3S group containing compounds. 1 is a useful trifluoromethylthiolating agent, because it is shelf-stable and easy-to-handle, and the reaction proceeds under mild conditions. Now, the studies of the biological activities of CF3S group substituted compounds are attracting interest. So, 1 is expected to be applied for the synthesis of bioactive compounds as well as pharmaceutical and agrochemical research.
T3143

References

R. Pluta, P. Nikolaienko, M. Rueping, Angew. Chem. Int. Ed. 2014, 53, 1650.

New Products

Bioscience

Product Highlight

Neuraminidase Inhibitor Suppressing the Influenza Viral Proliferation

Z0023
Influenza is an infectious disease caused by the influenza virus. The influenza virus has hemagglutinin, a glycoprotein on the surface of the viral particle. Hemagglutinin mediates the virus invasion by binding to N-acetylneuraminic acid (NANA), a sialic acid on the animal cell membranes. The infected cells replicate the viral genes followed by the release of viral particles from the cells to spread the infection. When they are released, the neuraminidase on the outside of the viral particle acts as an enzyme cleaving the sialic acid groups at the infected cell surface.1,2)
It was revealed in the 1970s that 2,3-dehydro-2-deoxy-N-acetylneuraminic acid (DANA), a sialic acid analogue, inhibits the influenza virus neuraminidase.3,4) Since then, zanamivir, a DANA derivative developed through rational drug design, has been used as an influenza antiviral.5) New antivirals based on DANA as neuraminidase inhibitors are being investigated today.6)

References

1)A. Moscona, N. Engl. J. Med. 2005, 353, 1363.
2)L. V. Gubareva, L. Kaiser, F. G. Hayden, Lancet 2000, 355, 827.
3)P. Meindl, G. Bodo, J. Lindner, P. Palese, Z. Naturforsch. Teil B 1971, 26, 792.
4)P. Meindl, G. Bodo, P. Palese, J. Schulman, H. Tuppy, Virology 1974, 58, 457.
5)M. Itzstein, W.-Y. Wu, G. B. Kok, M. S. Pegg, J. C. Dyason, B. Jin, T. Van Phan, M. L. Smythe, H. F. White, S. W. Oliver, P. M. Colman, J. N. Varghese, D. M. Ryan, J. M. Woods, R. C. Bethell, V. J. Hotham, J. M. Cameron, C. R. Penn, Nature 1993, 363, 418.
6)D. A. Boltz, J. R. Aldridge Jr, R. G. Webster, E. A. Govorkova, Drugs 2010, 70, 1349.

New Products

New Edition of TCIMail Quarterly Magazine – No. 164

TCIMAIL contains technical papers contributed by leading professors and scientists. We also introduce our new reagents in the fields of Synthetic Organic Chemistry, Materials Chemistry, Bioscience and Analytical Science. Examples of application and use are explained in an easy to understand way, using various schemes and charts.
Applications
- Reagent for Perovskite Solar Cells: Purified Lead(II) Iodide
- Useful Palladium Catalyst for C(sp3)-H Activation
- A New Efficient Extractant for Metal Ions Classified Soft Acids
- Symmetrical Pillar-shaped Macrocyclic Compound
- 5-hmdC: The Sixth Nucleoside of the Genome
- DRB: A Selective Inhibitor of Transcription Elongation by RNA Polymerase II
- Chemiluminescence Enhancer
- Peroxidase Detection
- Fluorescent Probe
- Glycogen Synthase Kinase (GSK) Inhibitor
- Phosphatidylinositol 3-Kinase Inhibitor

Chromatography -Chiral separation of Garner’s aldehyde

TCIDUal
Garner’s aldehyde is well-known as one of the most important chiral building blocks, and has been widely used as an intermediate in many syntheses. The chiral analysis of Garner’s aldehyde on our chiral column is shown above.
TCI Chiral MB-S(3 μm) gives a good separation.

TCI Catalogs & Product Brochures

websitetip
TCI has a wide variety of specific catalogs and product brochures. Most of them are available in PDF format and can be downloaded from our website.
Please click the following links to pick up the catalogs and brochures you are interested in:

TCI Website Tips

Reagent Guide Online –Product Information Page in TCI Website

TCI Reagent Guides, product catalogs by category, are very useful as reference book for finding reagents. Do you know Reagent Guides are available as online version in our website?
You click “Products” tab, then you can go around our product information by category easily.

Additionally, there are many online version specific features;
-New products that aren’t included in Reagent Guide are added every day.
-Product categories that aren’t included in Reagent Guides are available, and new categories are uploaded on a timely basis.

Please click the following product categories, and find your chemicals!

Exhibitions/Meetings/Shows

249th ACS National Meeting & Exposition

249th ACS
Booth# 1004
Colorado Convention Center
Denver, CO
March 22-26, 2015
» TCI exhibition information      » Event details

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