3/10/2015  TCI NEWS

We distribute TCI NEWS every four weeks, to our valued customers using research chemicals and chromatography products. We hope that you find this helpful for your research.

[Updated] Pamphlet - Click Chemistry

Click Chemistry is an effective and selective technique for strongly connecting two substrates to develop new functional compounds. This methodology has been widely used in various research fields, such as organic synthesis, functional materials, and bioscience.
Click Chemistry
• A number of products for Click Chemistry are listed, such as metal catalysts, ligands, ethynylation reagents, and building blocks.
• Reagents for “Cu-free” Click Chemistry are also listed.
• Review and application examples.

Synthetic Organic Chemistry

Research Article

Enantioselective Synthesis of Bicyclo Compounds Catalyzed by Rhodium and Benzoic Acid

Tanaka et al. have reported the synthesis of bicyclo[3.1.0]hexanes by the enantioselective cycloisomerization of 1,6-enynes using rhodium and benzoic acid catalysts. According to their results, the enantioselective cycloisomerization of 1,6-enynes possessing carbonyl groups at the enyne linkage proceeds by using [Rh(cod)2]BF4, (S)-(-)-SEGPHOS and benzoic acid as catalysts successfully giving 2-alkylidenebicyclo[3.1.0]hexanes. Bicyclo[3.1.0]hexane skeletons are found as core structures of natural products, so this reaction has attracted much attention as a useful synthetic method for these bicyclo compounds. Furthermore, they have also reported the one-pot synthesis of bicyclo lactones by the enantioselective cycloisomerization of 1,6-enynes followed by the tosyl acid-promoted lactonization.
B3961,S0929,B2635

References

K. Masutomi, K. Noguchi, K. Tanaka, J. Am. Chem. Soc. 2014, 136, 7627.

New Products

Bioscience

Product Highlight

Non-detergent Sulfobetaine (NDSB) Suitable for Protein Handling

H1399,S0813,B4030
  The solubilization of proteins in protein extraction and analysis requires the use of surfactants such as SDS and LDS, and denaturing agents urea and guanidine. However, the protein refolding and purification may be difficult in some cases since the interaction between surfactants and agents and proteins is strong.
  The amphiphilic small compounds containing cation and anion in a molecule such as 3-[(2-hydroxyethyl)dimethylammonio]propane-1-sulfonate (NDSB 211), 3-(1-pyridinio)propanesulfonate (NDSB 201), and 3-(4-tert-butyl-1-pyridinio)propanesulfonate (NDSB 256-4T) are called non-detergent sulfobetaines (NDSB), which have different properties from general surfactants. NDSB does not form micelles because of its smaller hydrophobic moiety and can solubilize proteins mildly. Also it has been reported that NDSB has the effect of prevention of protein denaturation by heat or acid, inhibition of protein aggregation, acceleration of protein refolding, and promotion of membrane protein extract.

References

L. Vuillard, T. Rabilloud, R. Leberman, C. Berthet-Colominas, S. Cusack, FEBS Lett. 1994, 353, 294.
L. Vuillard, C. Braun-Breton, T. Rabilloud, Biochem. J. 1995, 305, 337.
M. E. Goldberg, N. Expert-Bezançon, L. Vuillard, T. Rabilloud, Fold. Design 1996, 1, 21.
L. Vuillard, T. Rabilloud, M. E. Goldberg, Eur. J. Biochem. 1998, 256, 128.
N. Expert-Bezançon, T. Rabilloud, L. Vuillard, M. E. Goldberg, Biophys. Chem. 2002, 100, 469.
S. D’Amico, G. Feller, Anal. Biochem. 2009, 385, 389.
M. Hagihara, A. Takei, T. Ishii, F. Hayashi, K. Kubota, K. Wakamatsu, N. Nameki, FEBS Open Bio 2012, 2, 20.

New Products

New Edition of TCIMail Quarterly Magazine – No. 164

TCIMAIL contains technical papers contributed by leading professors and scientists. We also introduce our new reagents in the fields of Synthetic Organic Chemistry, Materials Chemistry, Bioscience and Analytical Science. Examples of application and use are explained in an easy to understand way, using various schemes and charts.
Applications
- Reagent for Perovskite Solar Cells: Purified Lead(II) Iodide
- Useful Palladium Catalyst for C(sp3)-H Activation
- A New Efficient Extractant for Metal Ions Classified Soft Acids
- Symmetrical Pillar-shaped Macrocyclic Compound
- 5-hmdC: The Sixth Nucleoside of the Genome
- DRB: A Selective Inhibitor of Transcription Elongation by RNA Polymerase II
- Chemiluminescence Enhancer
- Peroxidase Detection
- Fluorescent Probe
- Glycogen Synthase Kinase (GSK) Inhibitor
- Phosphatidylinositol 3-Kinase Inhibitor

Chromatography -A Chiral Column Suitable for the Separation of Small Molecule Compounds

TCIDUal
Garner’s aldehyde is a small molecule compound that is difficult to analyze with conventional chiral columns. Our chiral column “TCI Chiral” is able to separate small molecule chiral compounds such as Garner’s aldehyde. TCI Chiral MB-S (3 μm) gives a good separation.

Other Applications for Small Molecule Chiral Compounds
» Carvone
» 2-Chloropropionic Acid
» Butyl Lactate

TCI Catalogs & Product Brochures

websitetip
TCI has a wide variety of specific catalogs and product brochures. Most of them are available in PDF format and can be downloaded from our website.
Please click the following links to pick up the catalogs and brochures you are interested in:

TCI Website Tips

Reagent Guide Online –Product Information Page in TCI Website

TCI Reagent Guides, product catalogs by category, are very useful as reference for finding reagents. Do you know Reagent Guides are also available as online version in our website?
You click “Products” tab, then you can go around our product information by category easily.

Additionally, there are many online version specific benefits;
-New products that aren’t included in Reagent Guide are added every day.
-Product categories that aren’t included in Reagent Guides are available, and new categories are uploaded on a timely basis.

Please click the following product categories, and find your chemicals!

Exhibitions/Meetings/Shows

249th ACS National Meeting & Exposition

249th ACS
Booth# 1004
Colorado Convention Center
Denver, CO
March 22-26, 2015
» TCI exhibition information      » ACS details

2015 Polymer Society of Korea

Daejeon Convention Center
Expo-ro 107, Yuseong-gu, Daejeon, Korea
April 9-10, 2015
» TCI exhibition information      » Event details

The 115th General Meeting of the Korean Chemical Society

KINTEX
Goyang, Gyeonggi Province, Korea
April 15-17, 2015
» TCI exhibition information      » Event details

Other Information

TCI Facebook Page

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https://www.facebook.com/TCIchemicals

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