4/6/2015  TCI NEWS

We distribute TCI NEWS every four weeks, to our valued customers using research chemicals and chromatography products. We hope that you find this helpful for your research.

[NEW] Pamphlet - Silane Coupling Reagents

Silane coupling reagents used in research on surface modification, organic-inorganic hybrid materials, and self-assembled monolayers are listed. For ease of use, they are classified by chemical structure.
Silane Coupling
Typical Structures:
・Olefinyl Silanes
・Acryloyloxyalkyl Silanes
・Glycidyloxyalkyl Silanes
・Aminoalkyl Silanes

[New Edition] TCIMail Quarterly Magazine – No. 165

TCIMAIL contains technical papers contributed by leading professors and scientists. We also introduce our new reagents in the fields of Synthetic Organic Chemistry, Materials Chemistry, Bioscience and Analytical Science. Examples of application and use are explained in an easy to understand way, using various schemes and charts.
Chemistry Chat
- Focusing on the Elements - Compounds Composed of Two Elements (2)
Kentaro Sato

Applications
- Hybrid-type Oxidizing Catalyst Using Peracetic Acid as a Co-oxidizing Agent
- A New 3,3,3-trifluoropropenylation Reagent, Ikeda–Omote Reagent
- Redox Coenzymes
- JAK Inhibitor
- Bone Resorption Inhibitor
- Detergent for Biochemical Research

Synthetic Organic Chemistry

Research Article

Catalytic Asymmetric Vinylogous Conjugate Addition of Unsaturated Butyrolactones to α,β-Unsaturated Thioamides

  Shibasaki et al. have reported the catalytic asymmetric vinylogous conjugate addition of unsaturated butyrolactones to α,β-unsaturated thioamides using soft Lewis acid/Brønsted base cooperative catalysts. According to their results, the reaction proceeds with high enantioselectivity by using [Cu(CH3CN)4]PF6 as a soft Lewis acid, (R)-SEGPHOS as a ligand, and a tertiary amine as a Brønsted base, generating the conjugate adduct bearing consecutive tri- and tetrasubstituted stereogenic centers. This reaction can be conducted at room temperature through an operationally simple protocol. Then the thioamide functionality of the product can be transformed into various functional groups. Since butenolide units are found in a wide range of natural products and biologically active compounds, this reaction is expected to be a useful synthetic method for those compounds.
T2665,S0930

References

L. Yin, H. Takada, S. Lin, N. Kumagai, M. Shibasaki, Angew. Chem. Int. Ed. 2014, 53, 5327.

New Products

Bioscience

Product Highlight

A Constituent of Propolis with Various Bioactivities

P2088
Propolis (bee glue) is a mixture of tree resins and dyes collected from plants by honey bees, and their own secretion. Honey bees use it as a building material of the beehive, while humans have used its antibacterial and antitumor activities from B. C. E.
Caffeic acid phenethyl ester (CAPE) is a constituent of propolis, which has various bioactivities. It has been reported that CAPE inhibits NF-κB activation and has antineoplastic, antioxidant, anti-inflammatory, and cytostatic properties.

References

K. Natarajan, S. Singh, T. R. Burke, Jr, D. Grunberger, B. B. Aggarwal, Proc. Natl. Acad. Sci. USA 1996, 93, 9090.
J. H. Chen, C.-T. Ho, J. Agric. Food Chem. 1997, 45, 2374.
P. Michaluart, J. L. Masferrer, A. M. Carothers, K. Subbaramaiah, B. S. Zweifel, C. Koboldt, J. R. Mestre,
D. Grunberger, P. G. Sacks, T. Tanabe, A. J. Dannenberg, Cancer Res. 1999, 59, 2347.
T.-W. Chung, S.-K. Moon, Y.-C. Chang, J.-H. Ko, Y.-C. Lee, G. Cho, S.-H. Kim, J.-G. Kim, C.-H. Kim, FASEB J. 2004, 18, 1670.
M. Watabe, K. Hishikawa, A. Takayanagi, N. Shimizu, T. Nakaki, J. Biol. Chem. 2004, 279, 6017.
S. Akyol, Z. Ginis, F. Armutcu, G. Ozturk, M. R. Yigitoglu, O. Akyol, Cell Biochem. Funct. 2012, 30, 438.

New Products

Chromatography -A Chiral Column Suitable for the Separation of Small Molecule Compounds

TCIDUal
Garner’s aldehyde is a small molecule compound that is difficult to analyze with conventional chiral columns. Our chiral column “TCI Chiral” is able to separate small molecule chiral compounds such as Garner’s aldehyde. TCI Chiral MB-S (3 μm) gives a good separation.

Other Applications for Small Molecule Chiral Compounds
» Carvone
» 2-Chloropropionic Acid
» Butyl Lactate

TCI Catalogs & Product Brochures

websitetip
TCI has a wide variety of specific catalogs and product brochures. Most of them are available in PDF format and can be downloaded from our website.
Please click the following links to pick up the catalogs and brochures you are interested in:

TCI Website Tips

Reagent Guide Online –Product Information Page in TCI Website

TCI Reagent Guides, product catalogs by category, are very useful as reference for finding reagents. Do you know Reagent Guides are also available as online version in our website?
You click “Products” tab, then you can go around our product information by category easily.

Additionally, there are many online version specific benefits;
-New products that aren’t included in Reagent Guide are added every day.
-Product categories that aren’t included in Reagent Guides are available, and new categories are uploaded on a timely basis.

Please click the following product categories, and find your chemicals!

Exhibitions/Meetings/Shows

2015 Polymer Society of Korea

Daejeon Convention Center
Expo-ro 107, Yuseong-gu, Daejeon, Korea
April 9-10, 2015
» TCI exhibition information      » Event details

The 115th General Meeting of the Korean Chemical Society

KINTEX
Goyang, Gyeonggi Province, Korea
April 15-17, 2015
» TCI exhibition information      » Event details

Other Information

TCI Facebook Page

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https://www.facebook.com/TCIchemicals

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