10/5/2015  TCI NEWS

We distribute TCI NEWS every four weeks, to our valued customers using research chemicals and chromatography products. We hope that you find this helpful for your research.

[NEW] Pamphlet - Building Blocks for Organic Semiconductor

Building Blocks for Organic Semiconductor
Building blocks for synthesis of small molecule organic semiconductors and organic semiconducting polymers are listed.
Here are the typical product groups;

Building Blocks for Small Molecule Semiconductor
Building Blocks for Semiconducting Polymer
Derivatizing Reagents for Solubility Improvement

[New Edition] TCIMail Quarterly Magazine – No. 166

TCIMAIL contains technical papers contributed by leading professors and scientists. We also introduce our new reagents in the fields of Synthetic Organic Chemistry, Materials Chemistry, Bioscience and Analytical Science. Examples of application and use are explained in an easy to understand way, using various schemes and charts.
Research Article
- Invention of Synthetic Reactions Based on σ-Bond Activation
Tamejiro Hiyama
RDI Professor, Research and Development Initiative, Chuo University

Applications
- Nanodiamond
- Useful Copper Reagent for Coupling Reactions
- Ligands for Click Chemistry
- Non-detergent Sulfobetaines
- Cyclitol

Chemistry Chat

Focusing on the Elements - Naturally Occurring Organic Fluorine Compounds


Kentaro Sato

Valuable Fluorinated Compounds

One of the major trends in recent organic reaction development is the introduction of fluorine atom. Because fluorine is the most electronegative element of all elements, the overall property of a given molecule can be changed to great extent by introducing fluorine atom(s). The atomic radius of fluorine is similar to that of hydrogen at the same time, so the size of the molecule is not affected as much. Due to these properties, the number of compounds containing fluorine is increasing in pharmaceutical drugs and organic electronics materials and so is the demand for effective fluorination reactions.

[Related Product Brochure] Fluorinating Reagents, Building Blocks & Fluorinated Bioactive Compounds

Fluorinating Reagents, Building Blocks & Fluorinated Bioactive Compounds
Various fluorinating reagents, many fluorinated building blocks and fluorinated pharmaceutical ingredients are listed.
Here are the typical product groups;

Fluorinating Reagents
Trifluoromethylating Reagents
Perfluoroalkylating Reagents
Fluorinated Building Blocks
Fluorinated Bioactive Compounds

Synthetic Organic Chemistry

Research Article

Generation of the First 3,4-Piperidyne and its Cycloaddition Reactions for the Synthesis of Annulated Piperidines

  Garg et al. have reported the generation of the first 3,4-piperidyne and its cycloaddition reactions for the synthesis of annulated piperidines. According to their results, silyl triflate 1 is treated with CsF in the presence of several trapping agents to afford the corresponding cycloaddition products via 3,4-piperidyne intermediates. For example, in the case of using N-tert-butyl-α-phenylnitrone as a trapping agent, the cycloaddition reaction proceeds regioselectively to afford the isoxazoline product 2 in good yields. Since the compounds bearing piperidine scaffolds are efficient for the synthesis of pharmaceuticals, this reaction is expected to be a new synthetic method for those compounds.
C2204,B1701

References

Product Highlight

An Asymmetric Organocatalyst Having an Isothiourea Moiety

HBTM-2.1 (1) is an isothiourea derivative having two asymmetric carbons and is used as an asymmetric organocatalyst.1-4) 1 can be used as a catalyst for condensations of two different carbonyl components and consequently affording cyclic compounds by intramolecular cyclizations. For example, an acyl iminium cation intermediate 2 is generated by the reaction of 1 with an anhydride prepared from a carboxylic acid and pivaloyl chloride, followed by the asymmetric 1,4-addition with an unsaturated carbonyl compound giving an enolate intermediate 3. The formed intermediate 3, having an active amide moiety, is cyclized by the intramolecular cyclization from the enolate moiety to afford the desired 6-membered lactone derivative.1) The condensation reactions using 1 have wide availabilities because various cyclic compounds can be synthesized by replacing the unsaturated compounds with other ones. Especially, the synthesis of β-lactam derivatives using imines is considered as one of the efficient conversions.2)
D4808

References

New Products

Bioscience

New Products

Mixed-Mode columns (ODS + Ion-Exchange) for HPLC “TCI Dual series”

• Analysis of Thyroid hormones by TCI Dual ODS-CX15 (Cation-Exchange column)
ODS + Ion-Exchange

TCI Catalogs & Product Brochures

websitetip
TCI has a wide variety of specific catalogs and product brochures. Most of them are available in PDF format and can be downloaded from our website.
Please click the following links to pick up the catalogs and brochures you are interested in:

TCI Website Tips

Reagent Guide Online –Product Information Page on TCI Website

TCI Reagent Guides, product catalogs by category, are very useful as reference for finding reagents. Do you know Reagent Guides are also available as online version on our website?
You click “Products” tab, then you can go around our product information by category easily.

Additionally, benefits of online catalogs include;
-New products that aren't included in Reagent Guide are added every day.
-Product categories that aren’t included in Reagent Guides are available, and new categories are uploadedtimely.

Please click the following product categories, and find your chemicals!

Exhibitions/Meetings/Shows

116th General Meeting & Exhibition of the Korean Chemical Society

Daegu EXCO‎
Daegu, Korea
October 14-16, 2015
» TCI exhibition information      » Event details

10th AFMC International Medicinal Chemistry Symposium

International Convention Center Jeju‎
Jeju, Korea
October 18-21, 2015
» TCI exhibition information      » Event details

Other Information

TCI Facebook Page

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https://www.facebook.com/TCIchemicals

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