4/18/2016  TCI NEWS

We distribute TCI NEWS every four weeks, to our valued customers using research chemicals and chromatography products. We hope that you find this helpful for your research.

[New Edition] TCIMail Quarterly Magazine – No. 169

TCIMAIL contains technical papers contributed by leading professors and scientists. We also introduce our new reagents in the fields of Synthetic Organic Chemistry, Materials Chemistry, Bioscience and Analytical Science. Examples of application and use are explained in an easy way, using various schemes and charts.
Shoji Hara
Shoji Hara, Specially Appointed Professor
Graduate School of Engineering, Hokkaido University

Hypervalent iodine fluorides have been used as oxidants as well as fluorinating reagents. Among them, iodotoluene difluoride (p-TolIF2), is the most popular fluorinating reagent because it can be prepared without hazardous F2 gas, and stable enough to be used without special knowledge and techniques.
» Read more

[Related Leaflet] New Stable Fluorinating Reagent with Ease of Handling (Hara Reagent)

Hara Reagent
This product is easily handled crystalline compound consisting of IF5, pyridine and HF, and is expected as the alternative reagent of IF5 that is unstable in air.

- Air-stable and non-hygroscopic crystalline powder
- Widely applicable to various fluorinations of sulfides and thioacetals, etc.

[Pamphlet] Halogenation Reagents

It contains a wide variery of halogenation reagents that are essential for the research of synthetic organic chemistry.

- Fluorinating agents, chlorinating agents, brominating agents and iodinating agents are listed
- Fluorinating agents are listed separately as electrophilic and nucleophilic types

Reagent Guides 8th Edition

In these Reagent Guides, TCI products have been classified according to research fields, reaction types, applications and basic structures. Please click here to contact TCI local distributors or TCI for a Free Copy!
Synthetic Organic Chemistry & Materials Chemistry

Classification examples:

Synthetic Organic Chemistry
Asymmetric Organocatalysts / Cross-coupling Reaction Using Transition Metal Catalysts / Condensation & Active Esterification

Materials Chemistry
Solar Cell Research Reagents / OLED / Photochromic Compounds
Bioscience & Analytical Science

Classification examples:

Nucleosides / Amino Acids / Sugars / Lipids / Terpenes / Steroids / Antibodies

Analytical Science
GC Derivatizing Reagents / HPLC Labeling Reagents / HPLC Columns / Derivatization Reagents for MS

Synthetic Organic Chemistry

Research Article

β-Amination of Aliphatic Amides via the β-C(sp3)—H Bonds Activation

Yu et al. have reported the β-amination of aliphatic amides via β-C(sp3)—H bonds activation. According to their results, the β-C(sp3)—H bonds activation of amides has been achieved by using a catalytic system of a [Pd(allyl)Cl]2 complex and a tris[3,5-bis(trifluoromethyl)phenyl]phosphine ligand in combination with N-perfluorophenyl aliphatic amides directly coordinated with the palladium catalysts. In this reaction, aliphatic amides with a methyl group and other alkyl groups at the α-position are required for proceeding with the amination wherein the C(sp3)—H bond of the methyl group is selectively cleaved. Also, O-benzoyl hydroxylamines modified with an amino group of cyclic aliphatic amines such as morpholines and piperazines are used as aminating reagents, and the given products after the aminations are useful for the synthetic intermediates of bioactive compounds. Especially, when using a piperidone derivative as an aminating reagent, the synthetic product 6 can be converted to the β-amino acid by removing the piperidone unit.


Product Highlight

A New Julia-Type Reagent for Methylenation Reactions

1-Methyl-2-(methylsulfonyl)benzimidazole (1) is a sulfone derivative developed of its application by Ando et al. which is used as a Julia-Kocienski-type methylenation reagent. 1 reacts with aldehydes and ketones to afford the methylene moieties under mild conditions in one pot. In the methylenation reaction, Wittig reagent is often used but one equivalent of triphenylphosphine oxide is obtained as a by-product which is hard to remove. Therefore the Wittig reagent is unsuitable for use on a large scale. On the other hand, the benzimidazole derivative as a by-product in this reaction is able to be removed by partition, so that the purification can be done more easily.


New Products


New Products

HPLC Columns “TCI Chiral RP series”

• A unique stationary phase
  Polymaleimide (helical polymer) bearing chiral side groups coated on silica gel.
• Suitable for separation of carbonyl compounds and the others
  ex. Ketones, Esters, Carboxylic Acids, N-Protected Amino Acids, Alcohols, etc.
• High column load capacity
• Superior column longevity [Maximum pressure: 2900 psi (20 MPa)]
• Affordable price
TCI Chiral series

TCI Catalogs & Product Brochures

TCI has a wide variety of catalogs and product brochures. Most of them are available in PDF format and can be downloaded from our website.
Please click the following links to download catalogs and brochures you are interested in.

TCI Website Tips

Reagent Guide - Online Version Available on TCI Website

TCI Reagent Guides, product catalogs by category, are very useful as reference for finding reagents. Do you know Reagent Guides are also available as online version on our website?
You click “Products” tab, then you can go around our product information by category easily.

Additionally, benefits of online catalogs include;
-New products that aren't included in the paper version are added every day.
-Product categories that aren’t included in the paper version are available, and new categories are uploaded timely.

Please click the following product categories, and find your chemicals!


117th General Meeting & Exhibition of the Korean Chemical Society

Goyang, Korea
April 20-22, 2016
» TCI exhibition information      » Event details

The 5th Sungkyun International Solar Forum 2016 (SISF 2016)

600th Anniversary Hall, Sungkyunkwan University
Seoul, Korea
May 25-27, 2016
» TCI exhibition information      » Event details

Other Information

TCI Facebook Page

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