11/14/2016  TCI NEWS

We distribute TCI NEWS every four weeks, to our valued customers using research chemicals and chromatography products. We hope that you find this helpful for your research.

[New Edition] TCIMail Quarterly Magazine – No. 171

TCIMAIL contains technical papers contributed by leading professors and scientists. We also introduce our new reagents in the fields of Synthetic Organic Chemistry, Materials Chemistry, Bioscience and Analytical Science. Examples of application and use are explained in an easy way, using various schemes and charts.

Research Article
- Development of Novel Methodologies in Organic Synthesis Based on Ate Complex Formation
Keiichi Hirano, Assistant Professor
Graduate School of Pharmaceutical Sciences, The University of Tokyo
Masanobu Uchiyama, Professor
Graduate School of Pharmaceutical Sciences, The University of Tokyo
Chief Scientist (Joint Appointment), RIKEN

Research Article
- Furan Photo-oxidation Based Click Reactions: Labeling, Crosslinking and Conjugation of Peptides and Oligonucleotides under Physiological Conditions
Annemieke Madder, Professor
Department of Organic and Macromolecular Chemistry, Ghent University

Chemistry Chat
New Allotropes of Main Group Elements (2)
Kentaro Sato

Applications
- Visible Light Photoredox Catalysts
- A Ceramide-Trafficking Protein (CERT) Inhibitor
- Protein Kinase Inhibitor

[Brochure] HPLC Labeling Reagents

It contains very efficient labeling reagents for HPLC analysis and describes the labeling procedures.
A1096E
- It introduces suitable detection procedure for each labeling reagent and also introduces functional groups that can be labeled.
- All procedures are described with the applications.

TCI has a wide variety of product brochures. Most of them are available in PDF format and can be downloaded from our website.

» Other Product Brochures

[Featured Products] Novel Highly-sensitive Fluorescent Probes

Europium fluorophore DTBTA-Eu3+ labeled secondary antibodies (G0505, G0506) and streptavidin (S0993) have various features derived from DTBTA-Eu3+. Highly-sensitive detection with one order of magnitude compared to those of conventional fluorometric assays can be expected, since the background fluorescence from the sample matrix can be removed by time-resolved fluorometric measurement.

Synthetic Organic Chemistry

Research Article

Reductive Synthesis of Nitrones from N-Hydroxyamides Using an Iridium Catalyst

  Chida et al. have reported the reductive synthesis of nitrones from N-hydroxyamides using an iridium catalyst. According to their results, by using Vaska's catalyst [IrCl(CO)(PPh3)2] and 1,1,3,3-tetramethyldisiloxane, N-hydroxyamides are successfully transformed into the corresponding nitrones by two different types of reactions involving dehydrosilylations and hydrosilylations. This reaction shows high chemoselectivity even when various sensitive functional groups such as methyl esters are employed. Furthermore, it can be applied to the synthesis of macrocyclic nitrones, which are known to be difficult to synthesize by conventional methods. Since the obtained nitrones are promising key intermediates for the synthesis of biologically active compounds, this synthetic method has attracted considerable attention.
C2252,T1437

References

Product Highlight

Useful Hypervalent Iodine Compound for the Introduction of an Ethynyl Group

1-[(Trimethylsilyl)ethynyl]-1,2-benziodoxol-3(1H)-one (TMS-EBX) is a mild ethynylating reagent for which various examples of ethynylations have been reported. For instance, in the presence of TBAF, TMS-EBX reacts with active methylene compounds such as 1,3-dicarbonyl compounds or α-nitro carbonyl compounds and an ethynylation proceeds at the methylene moieties.1) Furthermore, this reagent is applied to total synthesis of natural products and the synthesis of (-)-lingzhiol2) and (+)-batzelladine3) have been reported as examples. In this way, the ethynylation reaction using TMS-EBX can be applied for further chemical functionalization of ethynes and click chemistry, so that it is expected to be used widely.
T3272

References

New Products

Bioscience

New Products

Mixed-Mode columns (ODS + Ion-Exchange) for HPLC “TCI Dual series”

Alzheimer Dementia Drugs
Analysis of Alzheimer Dementia Drugs by TCI Dual series

Reagent Guides 8th Edition

In these Reagent Guides, TCI products have been classified according to research fields, reaction types, applications and basic structures. Please click here to contact TCI local distributors or TCI for a Free Copy!
Synthetic Organic Chemistry & Materials Chemistry

Classification examples:

Synthetic Organic Chemistry
Asymmetric Organocatalysts / Cross-coupling Reaction Using Transition Metal Catalysts / Condensation & Active Esterification

Materials Chemistry
Solar Cell Research Reagents / OLED / Photochromic Compounds
Bioscience & Analytical Science

Classification examples:

Bioscience
Nucleosides / Amino Acids / Sugars / Lipids / Terpenes / Steroids / Antibodies

Analytical Science
GC Derivatizing Reagents / HPLC Labeling Reagents / HPLC Columns / Derivatization Reagents for MS

TCI has a wide variety of catalogs and product brochures. Most of them are available in PDF format and can be downloaded from our website.

» Other Catalogs & Product Brochures

TCI Website Tips

Reagent Guide - Online Version Available on TCI Website

TCI Reagent Guides, product catalogs by category, are very useful as reference for finding reagents. Do you know Reagent Guides are also available as online version on our website?
You click “Products” tab, then you can go around our product information by category easily.

Additionally, benefits of online catalogs include;
-New products that aren't included in the paper version are added every day.
-Product categories that aren’t included in the paper version are available, and new categories are uploaded timely.

Please click the following product categories, and find your chemicals!

Exhibitions/Meetings/Shows

Sialoglyco2016

The Fess Parker Doubletree Resort
Santa Barbara, California, USA
November 14–17, 2016
» TCI exhibition information      » Event details

Society for Glycobiology 2016 Annual Meeting

Hilton New Orleans Riverside
New Orleans, Louisiana, USA
November 19–22, 2016
» TCI exhibition information      » Event details

The 8th Asian Conference on Organic Electronics(A-COE 2016)

Kihada Hall, Kyoto University
Kyoto, Japan
December 5–7, 2016
» TCI exhibition information      » Event details

Other Information

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