1/24/2017  TCI NEWS

We distribute TCI NEWS every four weeks, to our valued customers using research chemicals and chromatography products. We hope that you find this helpful for your research.

[New Edition] TCIMAIL Quarterly Magazine – No. 172

TCIMAIL contains technical papers contributed by leading professors and scientists. We also introduce our new reagents in the fields of Synthetic Organic Chemistry, Materials Chemistry, Bioscience and Analytical Science. Examples of application and use are explained in an easy way, using various schemes and charts.

Research Article
- Asymmetric Catalysis with Chiral Bis(oxazolinyl)phenyl Transition-metal Complexes
Hisao Nishiyama
Emeritus Professor, Nagoya University

Chemistry Chat
New Allotropes of Main Group Elements (3)
Kentaro Sato

Applications
- New Umemoto’s Reagent II for Trifluoromethylation
- An Efficient Borafluorene for the Construction of Extended π-Conjugated Systems
- p-Type Organic Semiconductor: Soluble DNTT Precursor
- A Novel Hole Transport Material for Perovskite Solar Cells: H101
- Silyl Enol Ether Usable for Highly Stereoselective Aldol Reactions
- PI3K Inhibitor
- Glycogen Synthase Kinase (GSK) Inhibitor
- Tyrosine Kinase Iinhibitor: Biochanin A

[Featured Products] Endo-M & Glycosynthase - Chemoenzymatic Oligosaccharide Replacement

In recent years, the expectation of a therapeutic benefit for antibody drugs is growing and the development of industrial technology for antibody production is required. However, heterogeneity of glycosylation of antibody drugs has long been left unsolved. In this context, TCI achieved introduction of a MONO-form oligosaccharide to a defucosylated therapeutic antibody by using our enzyme products, “Endo-M” and “Glycosynthase”.

Synthetic Organic Chemistry

Research Article

Cycloaddition-hydrosilylation of 1,6-Eneynes Using a Cobalt/iminopyridine Complex

Lu et al. have reported the cobalt complex-catalyzed intramolecular cycloaddition-hydrosilylation of 1,6-eneynes. In this reaction, previously prepared and isolated cobalt-iminopyridine complex (Co-IP complex), from cobalt chloride and a ligand of trans-2,6-diisopropyl-N-(2-pyridylmethylene)aniline, is used as a pre-catalyst for this transformation. In the presence of hydrosilanes, the Co-IP complex is reduced by sodium borohydride to generate a cobalt-hydride species which catalyzes the subsequent intramolecular cycloaddition-hydrosilylation of 1,6-eneynes to afford the desired silyl group-substituted 5-membered rings. This reaction can be effectively used for synthesis of functionalized 5-membered cyclic compounds due to having a wide reaction scope.
D4652

References

Product Highlight

Chiral Derivatization Reagent Possessing a Pyridylthiourea Structure

  (R)-PyT-C, which was developed by Toyo’oka et al., is a useful chiral derivatization reagent possessing a pyridylthiourea structure for the enantiomeric separation and the quantitative determination of chiral amines in LC-ESI-MS/MS. In the presence of 2,2'-dipyridyl disulfide and triphenylphosphine as activation reagents, amines are labeled with (R)-PyT-C to afford the corresponding labeled amines. When enantiomeric mixtures of amines are employed, the diastereomeric labeled amines are given. The formed diastereomers are clearly separated by reversed-phase chromatography using an ODS column. Furthermore, the resulting derivatives show a characteristic product-ion (m/z 137.0) derived from (R)-PyT-C, and highly sensitive detection and quantitation are performed from the SRM (selected reaction monitoring) chromatograms. This procedure is also applied to the simultaneous separation and detection of chiral amines. Thus, this analytical procedure is expected to open up a wide range of possibilities for application in the field of metabolomics.
P2298

References

New Products

Life Science

New Products

Mixed-Mode columns (ODS + Ion-Exchange) for HPLC “TCI Dual series”

Analysis of Metal Ions by TCI Dual series
Metal Ions













Column:          TCI Dual ODS-CX15
Column Size :  4.6 mm I.D. × 150 mm, 5 μm
Mobile Phase:  Acetonitrile/Volatile buffer
Detection:       Corona CAD
Sample :          1. Na+
                        2. K+
                        3. Mg2+
                        4. Ca2+
                        5. Zn2+

Reagent Guides 8th Edition

In these Reagent Guides, TCI products have been classified according to research fields, reaction types, applications and basic structures. Please click here to contact TCI local distributors or TCI for a Free Copy!
Synthetic Organic Chemistry & Materials Chemistry

Classification examples:

Synthetic Organic Chemistry
Asymmetric Organocatalysts / Cross-coupling Reaction Using Transition Metal Catalysts / Condensation & Active Esterification

Materials Chemistry
Solar Cell Research Reagents / OLED / Photochromic Compounds
Bioscience & Analytical Science

Classification examples:

Bioscience
Nucleosides / Amino Acids / Sugars / Lipids / Terpenes / Steroids / Antibodies

Analytical Science
GC Derivatizing Reagents / HPLC Labeling Reagents / HPLC Columns / Derivatization Reagents for MS

TCI has a wide variety of catalogs and product brochures. Most of them are available in PDF format and can be downloaded from our website.

» Other Catalogs & Product Brochures

TCI Website Tips

Reagent Guide - Online Version Available on TCI Website

TCI Reagent Guides, product catalogs by category, are very useful as reference for finding reagents. Do you know Reagent Guides are also available as online version on our website?
You click “Products” tab, then you can go around our product information by category easily.

Additionally, benefits of online catalogs include;
-New products that aren't included in the paper version are added every day.
-Product categories that aren’t included in the paper version are available, and new categories are uploaded timely.

Please click the following product categories, and find your chemicals!

Exhibitions/Meetings/Shows

Asia-Pacific Hybrid and Organic Photovoltaics Conference (AP-HOPV17)

PACIFICO Yokohama
Kanagawa, JAPAN
February 3-4, 2017
» TCI exhibition information      » Event details

Organic Chemistry Division of Korean Chemical Society - 36th Symposium and General Meeting

Korea Research Institute of Chemical Technology
Daejeon, Korea
February 16, 2017
» TCI exhibition information      » Event details

The Polymer Society of Korea – 2017 Spring Meeting

Daejeon Convention Center
Daejeon, Korea
April 5-7, 2017
» TCI exhibition information      » Event details

119th KCS General Meeting & Exposition

KINTEX
Goyang, Korea
April 19-21, 2017
» TCI exhibition information      » Event details

Other Information

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